Skip to search formSkip to main content
You are currently offline. Some features of the site may not work correctly.

U 73975

Known as: U-73,975, U-73975 
 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
1994
1994
During a phase I clinical and pharmacologic trial, 26 patients with refractory solid tumors were treated with increasing doses of… Expand
1994
1994
1,2-Dihydro-1-(chloromethyl)-5-hydroxy-8-methyl-3H-furano[3,2-e]in dole (CFI) as a novel replacement of the… Expand
1993
1993
U-73,975 (U-73), U-77,779 (U-77), and U-80,244 (U-80) are analogs of the potent antitumor compound CC-1065. This class of drugs… Expand
1992
1992
Adozelesin (U-73975) is an extremely potent cytotoxic agent which causes 90% lethality, after 2 h exposure in vitro, of Chinese… Expand
  • figure I
  • figure 2
  • figure 3
  • figure 4
  • figure 5
1992
1992
Several new antitumor agents belonging to the class of minor groove binders that are able to form covalent bonds with DNA via a… Expand
Highly Cited
1992
Highly Cited
1992
The cyclopropylpyrroloindole analogues are DNA minor-groove binders containing a cyclopropyl group, which mediates N3-adenine… Expand
  • figure 1
  • figure 2
  • table 2
  • table 1
  • table 3
1992
1992
U-73,975 (U-73), a closely related synthetic analogue of the antitumor agent CC-1065, acts by binding tightly in the minor groove… Expand
1991
1991
U-73,975 (U-73) and U-77,779 (U-77), two analogues of the cyclopropylpyrroloindole antitumor antibiotic CC-1065, are promising… Expand
1991
1991
CC-1065, a cyclopropylpyrroloindole (CPI), is a highly potent antitumor DNA-alkylating agent. We have devised a simple method to… Expand
1990
1990
U-71,184 is a CC-1065 analogue which is highly cytotoxic in vitro and has a broad spectrum of antitumor activity in vivo. Against… Expand