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activation of phospholipase C activity

Known as: phospholipase C activation 
The initiation of the activity of the inactive enzyme phospolipase C as the result of a series of molecular signals generated as a consequence of a G… Expand
National Institutes of Health

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Broader (1)

phospholipase C-activating G-protein coupled receptor signaling pathway

Papers overview

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2015
2015
Inhibition of P2Y6 receptor-mediated phospholipase C activation and Ca(2+) signalling by prostaglandin E2 in J774 murine macrophages.
Extracellular nucleotides act as inflammatory mediators through activation of multiple purinoceptors. Under inflammatory… Expand
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2005
2005
Lysophosphatidylserine stimulates L2071 mouse fibroblast chemotactic migration via a process involving pertussis toxin-sensitive trimeric G-proteins.
Lysophosphatidylserine (LPS) may be generated after phosphatidylserine-specific phospholipase A2 activation. However, the effects… Expand
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2000
2000
Pathogenesis of a bleeding disorder characterized by platelet unresponsiveness to thromboxane A2.
A platelet disorder characterized by the absence of thromboxane A2 (TXA2)-induced platelet aggregation is a new clinical entity… Expand
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1996
1996
Neomycin inhibits histamine and thapsigargin mediated Ca2+ entry in DDT1 MF-2 cells independent of phospholipase C activation.
The histamine H1 receptor mediated increase in cytoplasmic Ca2+ ([Ca2+]i) was measured in the presence of the known phospholipase… Expand
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1995
1995
Aspartate mutation distinguishes ETA but not ETB receptor subtype-selective ligand binding while abolishing phospholipase C activation in both receptors.
The endothelin receptors, ETA and ETB, are G protein-coupled receptors (GPCR) that show distinctively different binding profiles… Expand
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1995
1995
Effects of oestradiol and tamoxifen on oxytocin-induced phospholipase C activation in human myometrial cells.
The role of oestradiol in the control of uterine responsiveness to oxytocin was investigated by measuring oxytocin-induced… Expand
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1991
1991
The mechanisms of endothelin action in vascular smooth muscle cells.
The mechanisms of actions were investigated in cultured rat aortic vascular smooth muscle A-10 cells. The A-10 cells have a… Expand
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1990
1990
Lateral mobility of the phospholipase C-activating vasopressin V1-type receptor in A7r5 smooth muscle cells: a comparison with the adenylate cyclase-coupled V2-receptor.
The present work examines lateral mobility of the vasopressin V1-type receptor, representing the first determination of lateral… Expand
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1988
1988
Studies of the Ca2+ requirements for glucose- and carbachol-induced augmentation of inositol trisphosphate and inositol tetrakisphosphate accumulation in digitonin-permeabilized islets. Evidence for…
The metabolism of D-glucose is believed to initiate and regulate insulin secretion by islet beta-cells, although the identity of… Expand
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1986
1986
Regulation of the phosphoinositide hydrolysis pathway in thrombin-stimulated platelets by a pertussis toxin-sensitive guanine nucleotide-binding protein. Evaluation of its contribution to platelet…
In platelets activated by thrombin, the hydrolysis of phosphatidylinositol 4,5-bisphosphate by phospholipase C produces inositol… Expand
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