Skip to search formSkip to main content
You are currently offline. Some features of the site may not work correctly.

aceclidine

Known as: 3-Acetoxyquinuclidine, 1-Azabicyclo(2.2.2)octan-3-ol, acetate (ester), 3-Quinuclidinol Acetate 
 
National Institutes of Health

Related topics

Related topics

8 relations
Aceclidine Salicylate

Narrower (4)

GlaucadrineGlaucostatGlaucotataceclidine hydrochloride

Broader (3)

MioticsParasympathomimetic AgentsQuinuclidines

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2007
Highly Cited
2007
Estimation of Agonist Activity at G Protein-Coupled Receptors: Analysis of M2 Muscarinic Receptor Signaling through Gi/o,Gs, and G15
We developed novel methods for analyzing the concentration-response curve of an agonist to estimate the product of observed… Expand
  • figure 1
  • figure 2
  • figure 4
  • figure 3
  • table 4
Highly Cited
2003
Highly Cited
2003
Correlation between pK(a) and reactivity of quinuclidine-based catalysts in the Baylis-Hillman reaction: discovery of quinuclidine as optimum catalyst leading to substantial enhancement of scope.
The reactivity of a variety of quinuclidine-based catalysts in the Baylis-Hillman reaction has been examined, and a… Expand
1998
1998
1,2,5-Thiadiazole analogues of aceclidine as potent m1 muscarinic agonists.
The acetyl group of the muscarinic agonist aceclidine 4 was replaced by various 1,2,5-thiadiazoles to provide a new series of… Expand
1996
1996
The interaction of the enantiomers of aceclidine with subtypes of the muscarinic receptor.
The pharmacological activity of the enantiomers of aceclidine was investigated in Chinese hamster ovary cells transfected with… Expand
1994
1994
Inhibition of aceclidine-stimulated outflow facility, accommodation and miosis in rhesus monkeys by muscarinic receptor subtype antagonists.
Aceclidine can dissociate accommodative and outflow facility responses in monkeys and humans. We sought to determine if different… Expand
Highly Cited
1991
Highly Cited
1991
Differential smooth muscle-like contractile properties of trabecular meshwork and ciliary muscle.
The contractile properties of bovine trabecular meshwork and ciliary muscle strips were investigated using an electromagnetic… Expand
Highly Cited
1986
Highly Cited
1986
The pharmacological assessment of RS 86 (2-ethyl-8-methyl-2,8-diazaspiro-[4,5]-decan-1,3-dion hydrobromide). A potent, specific muscarinic acetylcholine receptor agonist.
The effects of the compound RS 86 (2-ethyl-8-methyl-2,8-diazaspiro-[4,5]-decan-1,3-dion hydrobromide) in a number of in vitro and… Expand
1976
1976
A new probe for heterogeneity in muscarinic receptors: 2-methyl-spiro-(1, 3-dioxolane-4, 3')-quinuclidine.
The title compound (MSDQ) is a new muscarinic agonist related to 3-acetoxyquinuclidine (3-AcQ) but also of a highly rigid… Expand
1975
1975
A theoretical and experimental study of the semirigid cholinergic agonist 3-acetoxyquinuclidine.
The interaction of the two enantiomens of 3-acetoxyquinuclidine (3-AcQ) and of its N-methyl derivative with the cholinergic… Expand
1975
1975
Accommodative effects of aceclidine in the treatment of glaucoma.
In 18 patients, 2% pilocarpine, 2% pilocarpine plus tropicamide 10:1, and 2% aceclidine were tested with respect to the degree of… Expand
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy, Terms of Service, and Dataset License
ACCEPT & CONTINUE