• Publications
  • Influence
The long-term behavioural consequences of prenatal stress
  • M. Weinstock
  • Psychology, Medicine
  • Neuroscience & Biobehavioral Reviews
  • 1 August 2008
TLDR
Excess circulating maternal stress hormones alter the programming of foetal neurons, and together with genetic factors, the postnatal environment and quality of maternal attention, determine the behaviour of the offspring. Expand
Alterations induced by gestational stress in brain morphology and behaviour of the offspring
  • M. Weinstock
  • Medicine, Psychology
  • Progress in Neurobiology
  • 1 December 2001
TLDR
Prenatally-stressed rats show a reduced propensity for social interaction, increased anxiety in intimidating or novel situations and a reduction in cerebral asymmetry and dopamine turnover, consistent with those in schizophrenic humans, which may explain the precipitation of depressive symptoms or schizophrenia by psychosocial stress in later life. Expand
Prenatal stress selectively alters the reactivity of the hypothalamic-pituitary adrenal system in the female rat
TLDR
The data show that prenatal stress can cause permanent alterations in the behavior of both sexes in stressful situations but appears to cause a selective effect on the HPA axis in the female rat. Expand
Does Prenatal Stress Impair Coping and Regulation of Hypothalamic-Pituitary-Adrenal Axis?
  • M. Weinstock
  • Medicine, Psychology
  • Neuroscience & Biobehavioral Reviews
  • 31 January 1997
TLDR
The similarities in coping behavior and dysregulation of the HPA axis in PS animals to those in humans with depression, suggest that gestational stress, at a critical time during fetal development, may increase the propensity to develop this condition. Expand
The potential influence of maternal stress hormones on development and mental health of the offspring
  • M. Weinstock
  • Medicine, Psychology
  • Brain, Behavior, and Immunity
  • 1 July 2005
TLDR
Excess amounts of CRH and cortisol reaching the human fetal brain during periods of chronic maternal stress could alter personality and predispose to attention deficits and depressive illness through changes in neurotransmitter activity. Expand
Changes of spine density and dendritic complexity in the prefrontal cortex in offspring of mothers exposed to stress during pregnancy
TLDR
It is shown for the first time that the development of layer’II/III pyramidal neurons in the dorsal anterior cingulate and orbitofrontal cortex is significantly affected in offspring of mothers exposed to stress during pregnancy. Expand
Gender Differences in the Effects of Prenatal Stress on Brain Development and Behaviour
  • M. Weinstock
  • Psychology, Medicine
  • Neurochemical Research
  • 4 April 2007
TLDR
Genders may differ in the sensitivity of developing brain areas to stress hormones, while anxiety, depression and increased response of the HPA axis to stress are more prevalent in females. Expand
Selectivity of Cholinesterase Inhibition
TLDR
Eight cholinesterase inhibitors that reduce the inactivation of acetylcholine (ACh) have been tested in placebo-controlled trials in patients with Alzheimer’s disease and were found to improve cognitive function, or delay its rate of decline, in a significant proportion of patients. Expand
An experimental model of closed head injury in mice: pathophysiology, histopathology, and cognitive deficits.
TLDR
The results suggest that the modified model of CHI in mice can reproduce the posttraumatic sequelae observed in rats and show that some of the data obtained in this model are essentially similar to those observed in human head injury. Expand
Effect of varied gestational stress on acquisition of spatial memory, hippocampal LTP and synaptic proteins in juvenile male rats
TLDR
The alteration by prenatal stress in the relative amounts of scaffolding proteins and those which compose glutamate receptors could explain the depression of LTP and impairment in the acquisition of spatial learning. Expand
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