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abexinostat

Known as: 2-benzofurancarboxamide, 3-((dimethylamino)methyl)-n-(2-(4-((hydroxyamino)carbonyl)phenoxy)ethyl)-, 3-((dimethylamino)methyl)-N-(2-(4-(hydroxycarbamoyl)phenoxy)ethyl)-1-benzofuran-2-carboxamide, HDAC Inhibitor PCI-24781 
A broad-spectrum phenyl hydroxamic acid inhibitor of histone deacetylase (HDAC) with potential antineoplastic activity. Abexinostat inhibits several… 
National Institutes of Health

Related topics

Related topics

5 relations

Broader (3)

BenzofuransHistone deacetylase inhibitorHydroxamic Acids

Narrower (2)

CRA-024781PCI 24781

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Time dependent modulation of tumor radiosensitivity by a pan HDAC inhibitor: abexinostat
Despite prominent role of radiotherapy in lung cancer management, there is an urgent need for strategies increasing therapeutic… 
2016
2016
Histone deacetylase inhibitor abexinostat (S78454/PCI-24781) as a successful approach in a case of refractory peripheral angio-immunoblastic T-cell lymphoma, as a bridge to reduced intensity…
A 66-year-old woman presented in 2012 with an unintentional 10 kg weight loss, intermittent fevers, skin rash, generalized… 
Review
2015
Review
2015
Targeting New Candidate Genes by Small Molecules Approaching Neurodegenerative Diseases
Neurodegenerative diseases (NDs) are among the most feared of the disorders that afflict humankind for the lack of specific… 
2015
2015
Safety and Efficacy of Abexinostat, a Pan-Histone Deacetylase (HDAC) Inhibitor, in Non-Hodgkin Lymphoma and Chronic Lymphocytic Leukemia: Results of an Ongoing Phase 2 Study
Introduction: Histone deacetylase (HDAC) inhibitors, by blocking HDAC enzymes, can regulate acetylation states of histones and… 
2014
2014
In Silico Comparison of Maximum Tolerated Dose Determination in a Phase I Dose-Finding Framework: Application to Hematological Toxicity for a Histone Deacetylase Inhibitor Abexinostat, Co…
General attrition rates in drug development pipeline have been recognized as a necessity to shift gears towards new methodologies… 
2013
2013
Abstract LB-167: Phase I dose escalation study of abexinostat and doxorubicin in patients with metastatic sarcomas.
Intro/Objective: Several inhibitors of histone deacetylase have been shown to enhance chemotherapy induced apoptosis and reduce… 
2012
2012
Abexinostat (S78454/PCI-24781), an Oral Pan-Histone Deacetylas (HDAC) Inhibitor in Patients with Refractory or Relapsed Hodgkin's Lymphoma, Non-Hodgkin Lymphoma and Chronic Lymphocytic Leukemia…
Abstract 3643 Background. Abexinostat is a new hydroxymate-based pan-HDAC inhibitor of class I and II that induces apoptosis and… 
2010
2010
Abstract 5260: Bortezomib and HDAC inhibitor PCI-24781 combination therapy for neuroblastoma
Background: Neuroblastoma is an aggressive solid tumor with poor prognosis. Novel therapies are needed to help increase the… 
2009
2009
PP95 Predictive mRNA and microRNA markers of response to the HDAC inhibitor PCI-24781 in colorectal tumors
2007
2007
Sensitivity of primary hematopoietic tumors and tumor lines to the novel HDAC inhibitor PCI-24781
14062 PCI-24781 (formerly CRA-024781) is a novel HDAC inhibitor that is in phase I clinical trials in patients with solid and… 
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