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Zarnestra

National Institutes of Health

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tipifarnib

Papers overview

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2012
2012
Gemtuzumab ozogamicin (Mylotarg) in combination with tipifarnib (Zarnestra) in acute Myeloid Leukaemia
Background: The CD34 + CD38 - subset of AML cells is enriched for resistance to current chemotherapeutic agents and considered to… 
2008
2008
The farnesyltransferase inhibitor R115777 (ZARNESTRA®) enhances the pro-apoptotic activity of interferon-α through the inhibition of multiple survival pathways (International Journal of Cancer (2007…
2007
2007
Prevention of mouse lung tumors and modulation of DNA methylation by combined treatment with budesonide and R115777 (ZarnestraMT).
Budesonide (an anti-inflammatory glucocorticoid), R115777 (a farnesyl transferase inhibitor, Zarnestra, Tipifarnib) or… 
2005
2005
A phase I trial of the combination of erlotinib and tipifarnib in patients with advanced solid tumors
3000 Background: Preclinical data indicates that the EGFR tyrosine kinase inhibitor erlotinib demonstrates greater than additive… 
2005
2005
Expediting Oncology Drug Approvals: The Public Backlash Against the FDA and Opportunities to Reform
The FDA has made great strides over the past twenty years in loosening drug approval regulations to speed important, life-saving… 
2005
2005
The farnesyl transferase inhibitor (FTI) R115777 (Zarnestra®) inhibits the survival pathways activated by alpha Interferon in human epidermoid cancer cells
2258 We have previously reported that alpha interferon (IFN) and farnesyl transferase inhibitor (FTI) synergistically induce… 
2004
2004
The farnesyltransferase inhibitor Zarnestra synergizes with paclitaxel to induce mitotic arrest and apoptosis in multiple myeloma cells
3865 Despite significant recent advances in the treatment of multiple myeloma (MM), it remains an incurable disease with a median… 
2003
2003
Effect of farnesyl transferase inhibitor R115777 (Zarnestra) on the growth of fresh and cloned myeloma cells in vitro
2002
2002
Current Clinical Trials of R115777 (Zarnestra)
R115777 (Zarnestra) is an orally available methylquinolone derivative from Johnson & Johnson Pharmaceutical Research and… 
2001
2001
A phase I, clinical and pharmacokinetic trial of Zarnestra (farnesyl transferase inhibitor, R115777) and docetaxel : a promising combination in patients with solid tumors
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