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ZNRF3 gene

Known as: ZNRF3, FLJ22057, RNF203 
This gene is involved in protein ubiquitination and Wnt pathway inhibition.
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
The four R-spondin secreted ligands (RSPO1–RSPO4) act via their cognate LGR4, LGR5 and LGR6 receptors to amplify WNT signalling1… Expand
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Highly Cited
2015
Highly Cited
2015
Background/Aims: Micro-RNA (miR)-146b-5p is overexpressed in papillary thyroid carcinoma (PTC) and associated with extrathyroidal… Expand
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Highly Cited
2015
Highly Cited
2015
Significance Rnf43 (RING finger protein 43) and Znrf3 (zinc/RING finger protein 3), encoded by stem cell-specific Wnt (wingless… Expand
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Highly Cited
2015
Highly Cited
2015
Tumor suppressors ZNRF3 and RNF43 inhibit Wnt signaling through promoting degradation of Wnt coreceptors Frizzled (FZD) and LRP6… Expand
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Highly Cited
2014
Highly Cited
2014
Adrenocortical carcinomas (ACCs) are aggressive cancers originating in the cortex of the adrenal gland. Despite overall poor… Expand
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Review
2014
Review
2014
Lgr5 was originally discovered as a common Wnt target gene in adult intestinal crypts and colon cancer. It was subsequently… Expand
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Highly Cited
2013
Highly Cited
2013
The four R-spondin (Rspo) proteins are secreted agonists of Wnt signalling in vertebrates, functioning in embryogenesis and adult… Expand
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2013
2013
R-spondin proteins sensitize cells to Wnt signalling and act as potent stem cell growth factors. Various membrane proteins have… Expand
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Highly Cited
2012
Highly Cited
2012
R-spondin proteins strongly potentiate Wnt signalling and function as stem-cell growth factors. Despite the biological and… Expand
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Highly Cited
2012
Highly Cited
2012
LGR5+ stem cells reside at crypt bottoms, intermingled with Paneth cells that provide Wnt, Notch and epidermal growth factor… Expand
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