ZNRF3 gene

Known as: ZNRF3, FLJ22057, RNF203 
This gene is involved in protein ubiquitination and Wnt pathway inhibition.
National Institutes of Health

Topic mentions per year

Topic mentions per year

2010-2018
051020102018

Papers overview

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2015
2015
BACKGROUND/AIMS Micro-RNA (miR)-146b-5p is overexpressed in papillary thyroid carcinoma (PTC) and associated with extrathyroidal… (More)
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2015
2015
Tumor suppressors ZNRF3 and RNF43 inhibit Wnt signaling through promoting degradation of Wnt coreceptors Frizzled (FZD) and LRP6… (More)
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2015
2015
Rnf43 (RING finger protein 43) and Znrf3 (zinc/RING finger protein 3) (RZ) are two closely related transmembrane E3 ligases… (More)
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Highly Cited
2014
Highly Cited
2014
Adrenocortical carcinomas (ACCs) are aggressive cancers originating in the cortex of the adrenal gland. Despite overall poor… (More)
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2013
2013
The four R-spondin (Rspo) proteins are secreted agonists of Wnt signalling in vertebrates, functioning in embryogenesis and adult… (More)
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2013
2013
R-spondin proteins sensitize cells to Wnt signalling and act as potent stem cell growth factors. Various membrane proteins have… (More)
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2013
2013
E3 ubiquitin ligases regulate a variety of biological processes through the ubiquitin–proteasome system, together with ubiquitin… (More)
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2013
2013
Zinc RING finger 3 (ZNRF3) and its homolog RING finger 43 (RNF43) antagonize Wnt signaling in adult stem cells by ubiquitinating… (More)
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Highly Cited
2012
Highly Cited
2012
R-spondin proteins strongly potentiate Wnt signalling and function as stem-cell growth factors. Despite the biological and… (More)
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Highly Cited
2012
Highly Cited
2012
LGR5+ stem cells reside at crypt bottoms, intermingled with Paneth cells that provide Wnt, Notch and epidermal growth factor… (More)
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