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Gene transcription is controlled by transcriptional regulators acting with specific co-regulators to allow gene activation and… Expand The role of post-translational modification, such as sumoylation, in modulating the efficacy of doxorubicin (Dox) treatment… Expand BRCA1 exerts transcriptional repression through interaction with CtIP in the C-terminal BRCT domain and ZBRK1 in the central… Expand ABSTRACT Herpesviruses encode a set of core proteins essential for lytic replication of their genomes. Three of these proteins… Expand RING-finger proteins play crucial roles in ubiquitination events involved in diverse cellular processes including signal… Expand BackgroundSubtle functional deficiencies in highly conserved DNA repair or growth regulatory processes resulting from polymorphic… Expand The breast- and ovarian-specific tumor suppressor BRCA1 has been implicated in both activation and repression of gene… Expand ABSTRACT Induction of gene expression in response to DNA damage is important for repairing damaged DNA for cell survival… Expand More than 220 Kruppel-associated box-zinc finger protein (KRAB-ZFP) genes are encoded in the human genome. KRAB-ZFPs function as… Expand BRCA1 has been implicated in the transcriptional regulation of DNA damage-inducible genes that function in cell cycle arrest. To… Expand