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The nuclear exosome and its essential co-factor, the RNA helicase MTR4, play crucial roles in several RNA degradation pathways… Expand Short telomere syndromes manifest as familial idiopathic pulmonary fibrosis; they are the most common premature aging disorders… Expand Significance Aberrant or unwanted transcripts can be degraded by the RNA exosome with the help of the nuclear exosome-targeting… Expand The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. Substrate targeting is facilitated by its co… Expand The eukaryotic RNA exosome participates extensively in RNA processing and degradation. In human cells, three accessory factors… Expand Congenital gliobastoma multiforme (GBM) is rare and little is known about the molecular defects underlying the initiation and… Expand The Nuclear Exosome Targeting (NEXT) complex is a key cofactor of the mammalian nuclear exosome in the removal of Promoter… Expand The RNA exosome is a conserved degradation machinery, which obtains full activity only when associated with cofactors. The most… Expand The NCps (nucleocapsid proteins) of HIV-1 (HIV type 1), HIV-2 and SIV (simian immunodeficiency virus) are small highly basic… Expand Phosphorylation of c-Myc on threonine 58 (T58) stimulates its degradation by the Fbw7-SCF ubiquitin ligase. We used a… Expand