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By introducting the steroid sulfatase inhibitory pharmacophore into aromatase inhibitor 1 (YM511), two series of single agent… Expand The role of aromatase inhibitors in the treatment of hormone-dependent breast cancer is well established. However, it is now… Expand Aromatase inhibitors in clinical use block the biosynthesis of estrogens. Hydrolysis of estrone 3-sulfate by steroid sulfatase is… Expand Third generation aromatase inhibitors have excellent specificity. Some reports indicate that letrozole may have a minor effect on… Expand Estrogen deprivation therapy effectively prevents progress of endometriosis but the precise mechanism by which estrogen… Expand A series of [(4-bromobenzyl)(4-cyanophenyl)amino]azoles and their azine analogs, which have the side chain of the selective… Expand In order to study the potency of the 5-aminopyrimidine skeleton as an aromatase inhibitor, we synthesized various N,N… Expand Various 4-N-substituted amino-4H-1,2,4-triazole derivatives were synthesized and evaluated for aromatase-inhibitory activity (in… Expand The proliferation of MCF-7, human breast cancer cell line, was stimulated by testosterone and estradiol. The aromatase activity… Expand YM511 inhibited aromatase activities in microsomes from rat ovary and human placenta competitively (IC50s: 0.4 and 0.12 nM… Expand