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YM 511

Known as: YM-511, YM511 
 
National Institutes of Health

Papers overview

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2007
2007
By introducting the steroid sulfatase inhibitory pharmacophore into aromatase inhibitor 1 (YM511), two series of single agent… Expand
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2005
2005
The role of aromatase inhibitors in the treatment of hormone-dependent breast cancer is well established. However, it is now… Expand
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Review
2003
Review
2003
Third generation aromatase inhibitors have excellent specificity. Some reports indicate that letrozole may have a minor effect on… Expand
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2003
2003
Aromatase inhibitors in clinical use block the biosynthesis of estrogens. Hydrolysis of estrone 3-sulfate by steroid sulfatase is… Expand
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2003
2003
BACKGROUND A phase II study of a non-steroidal selective aromatase inhibitor, YM511, 4-[N-bromobenzyl]-N-(4H-1,2,4-triazol-4-yl… Expand
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1997
1997
Estrogen deprivation therapy effectively prevents progress of endometriosis but the precise mechanism by which estrogen… Expand
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1997
1997
A series of [(4-bromobenzyl)(4-cyanophenyl)amino]azoles and their azine analogs, which have the side chain of the selective… Expand
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1996
1996
Various 4-N-substituted amino-4H-1,2,4-triazole derivatives were synthesized and evaluated for aromatase-inhibitory activity (in… Expand
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1996
1996
The proliferation of MCF-7, human breast cancer cell line, was stimulated by testosterone and estradiol. The aromatase activity… Expand
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1995
1995
YM511 inhibited aromatase activities in microsomes from rat ovary and human placenta competitively (IC50s: 0.4 and 0.12 nM… Expand
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