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YM 12617

Known as: YM-12617 
National Institutes of Health

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3 relations

Broader (3)

Adrenergic alpha-AntagonistsSulfonamidesamsulosin

Papers overview

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2004
2004
Further studies on (±)-YM-12617, a potent and selective α1-adrenoceptor antagonist and its individual optical enantiomers
SummaryYM-12617, 5-[2-[[2-(o-ethoxyphenoxy)ethyl]amino]propyl]-2-methoxybenzenesulfonamide HCl is structurally novel, an… 
2004
2004
Studies on YM-12617: A selective and potent antagonist of postsynaptic α1-adrenoceptors
SummaryYM-12617, 5-[2-[[2-(2-ethoxyphenoxy)ethyl]-amino]propyl]-2-methoxybenzenesulfonamide HCl is a structurally new type of… 
1996
1996
Effect of Maturation on α-Adrenoceptor Activity in Newborn Piglet Mesentery
Abstract To characterize the mesenteric α1- and α2-adrenoceptor populations in newborn piglets, an extracorporeal circuit was… 
1992
1992
Effect of the optical isomers of YM-12617 on increased intra-urethral pressure induced by phenylephrine in anaesthetized dogs.
1. Effects of the individual optical isomers of YM-12617 (R, S 5-[2-[[2-(o-ethoxyphenoxy)ethyl]-amino]propyl]-2… 
1988
1988
Further characterization of the myocardial alpha-adrenoceptors mediating positive inotropic effects in the rabbit myocardium.
1988
1988
Electrical and mechanical properties of the capsular smooth muscles of the rabbit prostate in relation to the actions of the α1‐adrenoceptor blocker, YM‐12617
1 Electrical and mechanical properties of smooth muscle cells of the rabbit prostate capsule and the actions of the α1… 
Highly Cited
1987
Highly Cited
1987
Alpha-1 adrenoceptors in human prostate: characterization and alteration in benign prostatic hypertrophy.
Alpha-1 adrenoceptors in hypertrophied prostates of humans were characterized by a binding assay using [3H]prazosin as a… 
Highly Cited
1986
Highly Cited
1986
Alpha-1 adrenoceptor antagonist effects of the optical isomers of YM-12617 in rabbit lower urinary tract and prostate.
The alpha-1 adrenoceptor antagonist effects of the optical isomers of YM-12617 (5-[2-[[2-(o-ethoxyphenoxy)ethyl]amino]propyl]- 2… 
1986
1986
A difference in mode of antagonism between optical isomers of a potent selective alpha 1-adrenoceptor blocker (YM-12617) and norepinephrine in isolated rabbit iris dilator and aorta.
Optical isomers of YM-12617, a potent and selective alpha 1-adrenoceptor blocker, were tested on the rabbit iris dilator and… 
1985
1985
Studies on YM-12617: a selective and potent antagonist of postsynaptic alpha 1-adrenoceptors.
YM-12617, 5-[2-[[2-(2-ethoxyphenoxy)ethyl]-amino]propyl]-2 -methoxybenzenesulfonamide HCl is a structurally new type of extremely… 
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