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XRCC1 gene

Known as: X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 1 Gene, X-ray repair complementing defective repair in Chinese hamster cells 1, XRCC1 
This gene is involved in single-strand DNA break repair.
National Institutes of Health

Related topics

Related topics

5 relations
DNA RepairMalignant NeoplasmsSingle Strand Break RepairSister Chromatid Exchange

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2014
Highly Cited
2014
JWA reverses cisplatin resistance via the CK2—XRCC1 pathway in human gastric cancer cells
Gastric cancer is the third most common malignancy in China, with a median 5-year survival of only 20%. Cisplatin has been used… 
Highly Cited
2007
Highly Cited
2007
Genetic polymorphisms and haplotypes of DNA repair genes in childhood acute lymphoblastic leukemia
Polymorphisms of DNA repair genes can alter protein structure and may impair DNA repair capacity. Defects in repairing damaged… 
Highly Cited
2006
Highly Cited
2006
Genotoxicity associated to exposure to Prestige oil during autopsies and cleaning of oil-contaminated birds.
Highly Cited
2006
Highly Cited
2006
Which Gene is a Dominant Predictor of Response During FOLFOX Chemotherapy for the Treatment of Metastatic Colorectal Cancer, the MTHFR or XRCC1 Gene?
BackgroundCombination chemotherapy using oxaliplatin, 5-fluorouracil and folinic acid (FOLFOX) is known to be effective in the… 
Highly Cited
2005
Highly Cited
2005
Increased Risk of Oral Leukoplakia and Cancer Among Mixed Tobacco Users Carrying XRCC1 Variant Haplotypes and Cancer Among Smokers Carrying Two Risk Genotypes: One on Each of Two Loci, GSTM3 and…
An individual's susceptibility to oral precancer and cancer depends not only on tobacco exposure but also on the genotypes… 
2005
2005
MS-920: DNA repair gene polymorphisms, diet and colorectal cancer risk in Taiwan.
Highly Cited
2004
Highly Cited
2004
Polymorphisms of XRCC1 and risk of esophageal and gastric cardia cancer.
Highly Cited
2003
Highly Cited
2003
A prospective study of XRCC1 haplotypes and their interaction with plasma carotenoids on breast cancer risk.
The XRCC1 protein is involved in the base excision repair pathway through interactions with other proteins. Polymorphisms in the… 
Highly Cited
1998
Highly Cited
1998
The CHO XRCC1 mutant, EM9, deficient in DNA ligase III activity, exhibits hypersensitivity to camptothecin independent of DNA replication.
Highly Cited
1998
Highly Cited
1998
Methyl methanesulfonate-induced hprt mutation spectra in the Chinese hamster cell line CHO9 and its xrcc1-deficient derivative EM-C11.
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