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XRCC1 gene

Known as: X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 1 Gene, X-ray repair complementing defective repair in Chinese hamster cells 1, XRCC1 
This gene is involved in single-strand DNA break repair.
National Institutes of Health

Related topics

Related topics

5 relations
DNA RepairMalignant NeoplasmsSingle Strand Break RepairSister Chromatid Exchange

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2015
2015
Worldwide Distribution of Four SNPs in X‐Ray and Repair and Cross‐Complementing Group 1 (XRCC1)
X‐ray repair cross‐complementing group 1 (XRCC1) repairs single‐strand breaks in DNA. Several reports have shown the association… 
Review
2012
Review
2012
Predictive Value of XRCC1 Gene Polymorphisms on Platinum-Based Chemotherapy in Advanced Non–Small Cell Lung Cancer Patients: A Systematic Review and Meta-analysis
Purpose: Published data have shown conflicting results about the relationship between X-ray repair cross-complementing group 1… 
2011
2011
Impact of DNA repair genes polymorphism (XPD and XRCC1) on the risk of breast cancer in Egyptian female patients
The genes involved in DNA repair system play a crucial role in the protection against mutations. It has been hypothesized that… 
2010
2010
A functional −77T>C polymorphism in XRCC1 is associated with risk of breast cancer
X-ray repair cross-complementing 1 (XRCC1) plays a critical role in base excision repair and genetic variations of XRCC1 may be… 
Highly Cited
2007
Highly Cited
2007
XRCC1 and XPD polymorphisms and esophageal adenocarcinoma risk.
DNA damage is important in the pathogenesis of esophageal adenocarcinoma (EA). Polymorphic variants in DNA repair genes may be… 
Highly Cited
2006
Highly Cited
2006
Which Gene is a Dominant Predictor of Response During FOLFOX Chemotherapy for the Treatment of Metastatic Colorectal Cancer, the MTHFR or XRCC1 Gene?
BackgroundCombination chemotherapy using oxaliplatin, 5-fluorouracil and folinic acid (FOLFOX) is known to be effective in the… 
2006
2006
Polymorphisms of ADPRT Val762Ala and XRCC1 Arg399Glu and risk of breast cancer in Chinese women: a case control analysis.
Adenosine diphosphate ribosyl transferase (ADPRT) and X-ray repair cross-complementing 1 (XRCC1) are two major base excision… 
2003
2003
Influence of common XPD and XRCC1 variant alleles on p53 mutations in lung tumors
The DNA repair proteins XPD and XRCC1 are involved in the nucleotide and base excision repair of DNA lesions induced by many… 
1993
1993
Duplicated region of sequence similarity to the human XRCC1 DNA repair gene in the Schizosaccharomyces pombe rad4/cut5 gene.
Mutation in the rad4 gene of Schizosaccharomyces pombe confers sensitivity to both UV and ionizing radiation damage, as well as a… 
1992
1992
Expression of the polymorphic human DNA repair gene XRCC1 does not correlate with radiosensitivity in the cells of human head and neck tumor cell lines.
The human X-ray repair cross-complementing gene 1 (XRCC1) is highly polymorphic in the cells of human head and neck squamous cell… 
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