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XRCC1 gene

Known as: X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 1 Gene, X-ray repair complementing defective repair in Chinese hamster cells 1, XRCC1 
This gene is involved in single-strand DNA break repair.
National Institutes of Health

Related topics

Related topics

5 relations
DNA RepairMalignant NeoplasmsSingle Strand Break RepairSister Chromatid Exchange

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2005
Highly Cited
2005
XRCC1 is required for DNA single-strand break repair in human cells
The X-ray repair cross complementing 1 (XRCC1) protein is required for viability and efficient repair of DNA single-strand breaks… 
Highly Cited
2004
Highly Cited
2004
XPD and XRCC1 genetic polymorphisms are prognostic factors in advanced non-small-cell lung cancer patients treated with platinum chemotherapy.
PURPOSE Platinum agents cause DNA cross-linking and oxidative damage. Genetic polymorphisms of DNA repair genes are associated… 
Highly Cited
2001
Highly Cited
2001
XRCC1, XRCC3, XPD gene polymorphisms, smoking and (32)P-DNA adducts in a sample of healthy subjects.
DNA repair genes have an important role in protecting individuals from cancer-causing agents. Polymorphisms in several DNA repair… 
Highly Cited
2001
Highly Cited
2001
Polymorphisms in the DNA repair gene XRCC1 and breast cancer.
X-ray repair cross complementing group 1 (XRCC1) encodes a protein involved in base excision repair. We examined the association… 
Highly Cited
1999
Highly Cited
1999
XRCC1 polymorphisms: effects on aflatoxin B1-DNA adducts and glycophorin A variant frequency.
Hereditary genetic defects in DNA repair lead to increased risk of cancer. Polymorphisms in several DNA repair genes have been… 
Highly Cited
1999
Highly Cited
1999
Polymorphisms of DNA repair gene XRCC1 in squamous cell carcinoma of the head and neck.
Because reduced DNA repair capacity (phenotype) has been suggested as a risk factor for squamous cell carcinoma of the head and… 
Highly Cited
1998
Highly Cited
1998
XRCC1 Is Specifically Associated with Poly(ADP-Ribose) Polymerase and Negatively Regulates Its Activity following DNA Damage
ABSTRACT Poly(ADP-ribose) polymerase (PARP; EC 2.4.2.30 ) is a zinc-finger DNA-binding protein that detects and signals DNA… 
Highly Cited
1998
Highly Cited
1998
Structure of an XRCC1 BRCT domain: a new protein–protein interaction module
The BRCT domain (BRCA1 C‐terminus), first identified in the breast cancer suppressor protein BRCA1, is an evolutionarily… 
Highly Cited
1994
Highly Cited
1994
An interaction between the mammalian DNA repair protein XRCC1 and DNA ligase III
XRCC1, the human gene that fully corrects the Chinese hamster ovary DNA repair mutant EM9, encodes a protein involved in the… 
Highly Cited
1990
Highly Cited
1990
Molecular cloning of the human XRCC1 gene, which corrects defective DNA strand break repair and sister chromatid exchange
We describe the cloning and function of the human XRCC1 gene, which is the first mammalian gene isolated that affects cellular… 
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