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XK 469

Known as: XK469R, XK469, R(+)XK469 
The racemic form of a synthetic quinoxaline phenoxypropionic acid derivative with antineoplastic properties. XK469R selectively inhibits… 
National Institutes of Health

Related topics

Related topics

8 relations
DNA Repair InhibitionDNA Replication InhibitionMultidrug Resistance Inhibition processNCIt Antineoplastic Agent Terminology

Broader (1)

Quinoxalines

Papers overview

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Highly Cited
2016
Highly Cited
2016
Bifunctional tertiary amine-squaramide catalyzed asymmetric catalytic 1,6-conjugate addition/aromatization of para-quinone methides with oxindoles.
The asymmetric catalytic 1,6-addition of p-QMs with racemic oxindoles under the bifunctional catalysis of C2-symmetric dimeric… 
Highly Cited
2008
Highly Cited
2008
Enhanced cooperativity through design: pendant Co(III)--salen polymer brush catalysts for the hydrolytic kinetic resolution of epichlorohydrin (salen=N,N'-bis(salicylidene)ethylenediamine dianion).
The Co(III)--salen-catalyzed (salen=N,N'-bis(salicylidene)ethylenediamine dianion) hydrolytic kinetic resolution (HKR) of racemic… 
Highly Cited
2006
Highly Cited
2006
Highly enantioselective reductive cyclization of acetylenic aldehydes via rhodium catalyzed asymmetric hydrogenation.
Catalytic hydrogenation of acetylenic aldehydes 1a-12a using chirally modified cationic rhodium catalysts enables highly… 
Highly Cited
2005
Highly Cited
2005
Enantioselective direct intermolecular aldol reactions with enantiotopic group selectivity and dynamic kinetic resolution.
[reaction: see text] Proline-catalyzed aldol reactions of tetrahydro-4H-thipyranone with racemic 1,4-dioxa-8-thia-spiro[4.5… 
Highly Cited
2004
Highly Cited
2004
A "chiral aldehyde" equivalent as a building block towards biologically active targets.
Chiral gamma-aryloxybutenolides, readily accessible through dynamic kinetic asymmetric transformation (DYKAT) of racemic… 
Highly Cited
2002
Highly Cited
2002
Novel achiral biphenol-derived diastereomeric oxovanadium(IV) complexes for highly enantioselective oxidative coupling of 2-naphthols.
Optically pure 1,1’-binaphthol and its derivatives have been evaluated as versatile chiral auxiliaries and ligands in asymmetric… 
Highly Cited
2002
Highly Cited
2002
4-Aryloxybutenolides as "chiral aldehyde" equivalents: an efficient enantioselective synthesis of (+)-brefeldin a.
4-(2'-Naphthoxy)-2-butenolide, readily available with high enantiopurity by a dynamic kinetic asymmetric transformation (DYKAT… 
Highly Cited
1999
Highly Cited
1999
Butadiene diolepoxide- and diepoxybutane-derived DNA adducts at N7-guanine: a high occurrence of diolepoxide-derived adducts in mouse lung after 1,3-butadiene exposure.
Butadiene (BD) is a high production volume chemical and is known to be tumorigenic in rodents. BD is metabolized to butadiene… 
Highly Cited
1999
Highly Cited
1999
Plant and soil enantioselective biodegradation of racemic phenoxyalkanoic herbicides.
The biodegradation of the chiral phenoxyalkanoic herbicides 2-(2,4-dichlorophenoxy)propionic aid (2,4-DP) and 2-(4-chloro-2… 
Highly Cited
1985
Highly Cited
1985
Antiinvasive effect of racemic 1-O-octadecyl-2-O-methylglycero-3-phosphocholine on MO4 mouse fibrosarcoma cells in vitro.
Alkyl-lysophospholipids have been shown to possess antitumoral activity in animal and in human tumors. Among them, racemic 1-O… 
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