Enantioselective synthesis of Amaryllidaceae alkaloids (+)-vittatine, (+)-epi-vittatine, and (+)-buphanisine.
- Meng-Xue Wei, Cheng-Tao Wang, Chun‐An Fan
- ChemistryChemistry - An Asian Journal
- 1 September 2013
The addition of α-cyanoketones to acrylates under bifunctional organocatalysis was used to construct the unique arylic all-carbon quaternary stereocenter, which is synthetically crucial in the chemical synthesis of optically pure cis-aryl hydroindole alkaloids.
Formal syntheses of (+/-)-stemonamine and (+/-)-cephalotaxine.
- Yu‐Ming Zhao, P. Gu, Fu‐Min Zhang
- ChemistryJournal of Organic Chemistry
- 25 March 2009
A short and efficient approach to aza-quaternary pyrrolo[1,2-a]azepine 8 and aza the crucial intermediates for syntheses of stemonamine and cephalotaxine has been developed on the basis of the key intramolecular Schmidt reaction of symmetric azido-diones 5 and 18, respectively.
Semipinacol rearrangement in natural product synthesis.
- Zhenlei Song, Chun‐An Fan, Y. Tu
- BiologyChemical Reviews
- 18 August 2011
This research presents a novel and scalable approach called “Smartphone Drug Targeting” that allows for real-time decision-making and real-world application in the field of drug discovery and development.
Asymmetric catalytic 1,6-conjugate addition/aromatization of para-quinone methides: enantioselective introduction of functionalized diarylmethine stereogenic centers.
- Wen-Dao Chu, Le-Fen Zhang, Chun‐An Fan
- ChemistryAngewandte Chemie
- 26 August 2013
Brønsted Acid catalyzed enantioselective semipinacol rearrangement for the synthesis of chiral spiroethers.
- Qing-Wei Zhang, Chun‐An Fan, Zhi‐Min Chen
- ChemistryAngewandte Chemie
- 26 October 2009
Organocatalytic asymmetric vinylogous alpha-ketol rearrangement: enantioselective construction of chiral all-carbon quaternary stereocenters in spirocyclic diketones via semipinacol-type 1,2-carbon…
- E. Zhang, Chun‐An Fan, Y. Tu, Fu‐Min Zhang, Yanling Song
- ChemistryJournal of the American Chemical Society
- 28 September 2009
The catalytic enantioselective synthesis of all-carbon quaternary stereogenic centers in spirocyclic diketones has been achieved for the first time by an unprecedented asymmetric vinylogous…
Microwave-promoted three-component coupling of aldehyde, alkyne, and amine via C-H activation catalyzed by copper in water.
- Lei Shi, Y. Tu, Min Wang, Fu‐Min Zhang, Chun‐An Fan
- ChemistryOrganic Letters
- 24 February 2004
The preliminary experiment using (S)-proline methyl ester as a chiral source demonstrated that it could be developed to be a direct and highly diastereoselective method for construction of chiral propargylamines.
Diastereoselective and Enantioselective Synthesis of Unsymmetric β,β-Diaryl-α-Amino Acid Esters via Organocatalytic 1,6-Conjugate Addition of para-Quinone Methides.
- Xiang‐Zhi Zhang, Yuhua Deng, Chun‐An Fan
- Chemistry, BiologyJournal of Organic Chemistry
- 9 June 2016
A novel strategy based on phase transfer catalysis for the diastereoselective and enantioselective direct assembly of unsymmetric β,β-diaryl-α-amino acid esters via 1,6-conjugate addition of…
Spirocyclopropanation Reaction of para-Quinone Methides with Sulfonium Salts: The Synthesis of Spirocyclopropanyl para-Dienones.
- Xiang‐Zhi Zhang, Ji-Yuan Du, Chun‐An Fan
- ChemistryJournal of Organic Chemistry
- 4 March 2016
A novel DBU-mediated stereoselective spirocyclopropanation of para-quinone methides with sulfonium salts has been developed on the basis of the mode involving a 1,6-conjugate addition/intramolecular…
Enantioselective Synthesis of Functionalized 4-Aryl Hydrocoumarins and 4-Aryl Hydroquinolin-2-ones via Intramolecular Vinylogous Rauhut-Currier Reaction of para-Quinone Methides.
- Xiang‐Zhi Zhang, K. Gan, Chun‐An Fan
- Chemistry, BiologyOrganic Letters
- 5 June 2017
This intramolecular mode for the catalytic enantioselective 1,6-conjugate addition of p-QMs has been explored for the first time, delivering two types of synthetically important heterocycles in high yields and enantiOSElectivites.
...
...