Enantioselective synthesis of Amaryllidaceae alkaloids (+)-vittatine, (+)-epi-vittatine, and (+)-buphanisine.
The addition of α-cyanoketones to acrylates under bifunctional organocatalysis was used to construct the unique arylic all-carbon quaternary stereocenter, which is synthetically crucial in the chemical synthesis of optically pure cis-aryl hydroindole alkaloids.
Formal syntheses of (+/-)-stemonamine and (+/-)-cephalotaxine.
A short and efficient approach to aza-quaternary pyrrolo[1,2-a]azepine 8 and aza the crucial intermediates for syntheses of stemonamine and cephalotaxine has been developed on the basis of the key intramolecular Schmidt reaction of symmetric azido-diones 5 and 18, respectively.
Semipinacol rearrangement in natural product synthesis.
This research presents a novel and scalable approach called “Smartphone Drug Targeting” that allows for real-time decision-making and real-world application in the field of drug discovery and development.
Asymmetric catalytic 1,6-conjugate addition/aromatization of para-quinone methides: enantioselective introduction of functionalized diarylmethine stereogenic centers.
Brønsted Acid catalyzed enantioselective semipinacol rearrangement for the synthesis of chiral spiroethers.
Organocatalytic asymmetric vinylogous alpha-ketol rearrangement: enantioselective construction of chiral all-carbon quaternary stereocenters in spirocyclic diketones via semipinacol-type 1,2-carbon…
- E. Zhang, Chun‐An Fan, Y. Tu, Fu‐Min Zhang, Yanling Song
- ChemistryJournal of the American Chemical Society
- 28 September 2009
The catalytic enantioselective synthesis of all-carbon quaternary stereogenic centers in spirocyclic diketones has been achieved for the first time by an unprecedented asymmetric vinylogous…
Microwave-promoted three-component coupling of aldehyde, alkyne, and amine via C-H activation catalyzed by copper in water.
The preliminary experiment using (S)-proline methyl ester as a chiral source demonstrated that it could be developed to be a direct and highly diastereoselective method for construction of chiral propargylamines.
Diastereoselective and Enantioselective Synthesis of Unsymmetric β,β-Diaryl-α-Amino Acid Esters via Organocatalytic 1,6-Conjugate Addition of para-Quinone Methides.
A novel strategy based on phase transfer catalysis for the diastereoselective and enantioselective direct assembly of unsymmetric β,β-diaryl-α-amino acid esters via 1,6-conjugate addition of…
Spirocyclopropanation Reaction of para-Quinone Methides with Sulfonium Salts: The Synthesis of Spirocyclopropanyl para-Dienones.
A novel DBU-mediated stereoselective spirocyclopropanation of para-quinone methides with sulfonium salts has been developed on the basis of the mode involving a 1,6-conjugate addition/intramolecular…
Enantioselective Synthesis of Functionalized 4-Aryl Hydrocoumarins and 4-Aryl Hydroquinolin-2-ones via Intramolecular Vinylogous Rauhut-Currier Reaction of para-Quinone Methides.
This intramolecular mode for the catalytic enantioselective 1,6-conjugate addition of p-QMs has been explored for the first time, delivering two types of synthetically important heterocycles in high yields and enantiOSElectivites.