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XBP1 gene

Known as: XBP1, X BOX-BINDING PROTEIN 1, X-Box Binding Protein 1 Gene 
This gene is involved in the transcription of major histocompatibility complex class II genes and the response to endoplasmic reticulum stress.
National Institutes of Health

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Homo sapiensTranscriptional RegulationX-Box Binding Protein 1X-Box Binding Protein 1, Human

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XBP1 wt Allele

Papers overview

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2020
2020
LncRNA TUG1 promotes tumor growth and metastasis of esophageal squamous cell carcinoma by regulating XBP1 via competitively binding to miR-498.
Esophageal squamous cell carcinoma (ESCC) is a major subtype of esophageal cancer with high mortality. Previous reports suggested… 
2017
2017
TLR7‐mediated activation of XBP1 correlates with the IFN&agr; production in humans
2014
2014
Transcriptional repression of plasma cell differentiation is orchestrated by aberrant over‐expression of the ETS factor SPIB in Waldenström macroglobulinaemia
In Waldenström macroglobulinaemia (WM), the mechanism(s) responsible for repression of B‐cell differentiation remains unknown. We… 
Highly Cited
2013
Highly Cited
2013
Vascular Endothelial Cell Growth–Activated XBP1 Splicing in Endothelial Cells Is Crucial for Angiogenesis
Background— Vascular endothelial cell growth factor plays a pivotal role in angiogenesis via regulating endothelial cell… 
2013
2013
Unspliced XBP1 controls autophagy through FoxO1
Protein homeostasis in higher eukaryotes is balanced by a dynamic network of adaptive mechanisms, including the unfolded protein… 
2013
2013
UBC9 regulates the stability of XBP1, a key transcription factor controlling the ER stress response.
XBP1 is a key transcription factor regulating the mammalian endoplasmic reticulum (ER) stress response, which is a cytoprotective… 
2011
2011
Relationships of ESR1 and XBP1 expression in human breast carcinoma and stromal cells isolated by laser capture microdissection compared to intact breast cancer tissue
Results from investigations of human genomics which utilize intact tissue biopsy specimens maybe compromised due to a host of… 
Highly Cited
2009
Highly Cited
2009
Preliminary evidence on the association between XBP1-116C/G polymorphism and response to prophylactic treatment with valproate in bipolar disorders
2008
2008
Attenuated BDNF-induced upregulation of GABAergic markers in neurons lacking Xbp1.
Highly Cited
2000
Highly Cited
2000
CLN1 and Its Repression by Xbp1 Are Important for Efficient Sporulation in Budding Yeast
ABSTRACT Xbp1, a transcriptional repressor of Saccharomyces cerevisiae with homology to Swi4 and Mbp1, is induced by stress and… 
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