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WHI-07

Known as: WHI 07 
National Institutes of Health

Papers overview

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2005
2005
Antileukemic Activity and Cellular Metabolism of the Aryl Phosphate Derivative of Bromo-Methoxy Zidovudine (Compound WHI-07)
Summary The novel aryl phosphate derivative of bromo-methoxy zidovudine (ZDV/AZT) (compound WHI-07, CAS 213982-96-8) was found to… 
2004
2004
Antiretroviral Spermicide WHI-07 Prevents Vaginal and Rectal Transmission of Feline Immunodeficiency Virus in Domestic Cats
ABSTRACT WHI-07 [5-bromo-6-methoxy-5,6-dihydro-3′-azidothymidine-5′-(p-bromophenyl)-methoxy alaninyl phosphate] is a novel dual… 
2002
2002
Pre-clinical safety evaluation of novel nucleoside analogue-based dual-function microbicides (WHI-05 and WHI-07).
Compounds WHI-05 [5-bromo-6-methoxy-5,6-dihydro-3'-azidothymidine-5'-(p-methoxyphenyl)-methoxyalaninyl phosphate] and WHI-07 [5… 
2001
2001
Lack of adverse effects on fertility of female cd‐1 mice exposed to repetitive intravaginal gel–microemulsion formulation of a dual‐function anti‐HIV agent: aryl phosphate derivative of bromo‐methoxy…
5‐bromo‐6‐methoxy‐5,6‐dihydro‐3′‐azidothymidine‐5′‐(p‐bromophenyl) methoxyalaninyl phosphate (WHI‐07), a novel bromo‐methoxy… 
2001
2001
Short-Term (13-week) toxicity study of 5-bromo-6-methoxy-5,6-dihydro-3'-azidothymidine-5'-(p-bromophenyl) methoxyalaninyl phosphate (WHI-07), a novel anti-HIV and contraceptive agent, in B6C3F1 mice.
The zidovudine derivative, WHI-07 (5-bromo-6-methoxy-5,6-dihydro-3'-azidothymidine-5'-(p-bromophenyl) methoxyalaninyl phosphate… 
2001
2001
Thymidine Kinase-Independent Intracellular Delivery of Bioactive Nucleotides by Aryl Phosphate Derivatives of Bromo-Methoxy Zidovudine (Compounds WHI-05 and WHI-07) in Normal Human Female Genital…
Abstract The compounds WHI-05 (5-bromo-6-methoxy-5,6-dihydro-3′-azidothymidine-5′-[p-methoxyphenyl] methoxyalaninyl phosphate… 
2000
2000
Structural Requirements for Potent Human Spermicidal Activity of Dual-Function Aryl Phosphate Derivative of Bromo-Methoxy Zidovudine (Compound WHI-07)1
Abstract WHI-07, a novel bromo-methoxy-substituted aryl phosphate derivative of zidovudine (ZDV), is a potent dual-function… 
2000
2000
Evaluation of subchronic (13‐week) and reproductive toxicity potential of intravaginal gel–microemulsion formulation of a dual‐function phenyl phosphate derivative of bromo‐methoxy zidovudine…
Heterosexual transmission of human immunodeficiency virus (HIV) accounts for 90% of all new infections worldwide and… 
Review
1999
Review
1999
Prophylactic contraceptives for HIV/AIDS.
The current pandemic of sexually transmitted human immunodeficiency virus (HIV) infection--the causative agent of acquired… 
Highly Cited
1999
Highly Cited
1999
Synthesis, characterization and preclinical formulation of a dual-action phenyl phosphate derivative of bromo-methoxy zidovudine (compound WHI-07) with potent anti-HIV and spermicidal activities.
In a systematic effort to develop a microbicide contraceptive capable of preventing transmission of human immunodeficiency virus… 
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