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WDFY2 gene

Known as: ZFYVE22, WD Repeat and FYVE Domain Containing Gene, WD repeat and FYVE domain containing 2 
This gene may play a role in ligand binding.
National Institutes of Health

Related topics

Related topics

4 relations
Ligand BindingMetal Ion BindingWDFY1 geneWDFY2 protein, human

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2020
2020
WDFY2 Potentiates Hepatic Insulin Sensitivity and Controls Endosomal Localization of the Insulin Receptor and IRS1/2
Endosomes help activate the hepatic insulin-evoked Akt signaling pathway, but the underlying regulatory mechanisms are unclear… 
2019
2019
Genome‐wide DNA methylation investigation of glucocorticoid exposure within buccal samples
Glucocorticoids play a major role in regulating the stress response, and an imbalance of glucocorticoids has been implicated in… 
2019
2019
Population-based genome-wide association study of cognitive decline in older adults free of dementia: identification of a novel locus for the attention domain
2019
2019
Depletion of MLKL inhibits invasion of radioresistant nasopharyngeal carcinoma cells by suppressing epithelial-mesenchymal transition.
Background To examine whether MLKL participated in the invasion of radiosensitive nasopharyngeal carcinoma (NPC) cell (CNE-2) and… 
2018
2018
Genetic architecture and candidate genes detected for chicken internal organ weight with a 600 K single nucleotide polymorphism array
Objective Internal organs indirectly affect economic performance and well-being of animals. Study of internal organs during later… 
2017
2017
Overexpression of WDFY2 inhibits prostate cancer cell growth and migration via inactivation of Akt pathway
Prostate cancer is the most commonly diagnosed malignancy and is the second leading deadly reason among male cancer. WDFY2, which… 
2017
2017
A Genome-Wide Association Study and Complex Network Identify Four Core Hub Genes in Bipolar Disorder
Bipolar disorder is a common and severe mental illness with unsolved pathophysiology. A genome-wide association study (GWAS) has… 
2014
2014
CDKN2D-WDFY2 Is a Cancer-Specific Fusion Gene Recurrent in High-Grade Serous Ovarian Carcinoma
Ovarian cancer is the fifth leading cause of cancer death in women. Almost 70% of ovarian cancer deaths are due to the high-grade… 
Review
2007
Review
2007
Evolutionarily conserved structural and functional roles of the FYVE domain.
The FYVE domain is an approx. 80 amino acid motif that binds to the phosphoinositide PtdIns3P with high specificity and affinity… 
Highly Cited
2006
Highly Cited
2006
The WD40 and FYVE domain containing protein 2 defines a class of early endosomes necessary for endocytosis
The FYVE domain binds with high specificity and avidity to phosphatidylinositol 3-phosphate. It is present in ≈30 proteins in… 
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