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WAS gene

Known as: WASPA, WASP, Wiskott-Aldrich syndrome 
This gene is involved in signal transduction and plays a role in cell communication and organization.
National Institutes of Health

Related topics

Related topics

7 relations
Cytoskeletal ModelingSignal TransductionWAS protein, humanWAS wt Allele

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2010
2010
Critical requirement for the Wiskott-Aldrich syndrome protein in Th2 effector function.
Patients with Wiskott-Aldrich syndrome (WAS) have numerous immune cell deficiencies, but it remains unclear how abnormalities in… 
Highly Cited
2008
Highly Cited
2008
Wiskott-Aldrich syndrome protein deficiency in B cells results in impaired peripheral homeostasis
To more precisely identify the B-cell phenotype in Wiskott-Aldrich syndrome (WAS), we used 3 distinct murine in vivo models to… 
Highly Cited
2005
Highly Cited
2005
Defective nuclear translocation of nuclear factor of activated T cells and extracellular signal-regulated kinase underlies deficient IL-2 gene expression in Wiskott-Aldrich syndrome.
Review
2005
Review
2005
WASP and the phenotypic range associated with deficiency.
PURPOSE OF REVIEW This review reports on the range of clinical phenotypes that are caused by mutations in the Wiskott-Aldrich… 
Highly Cited
2004
Highly Cited
2004
Differential contribution of Wiskott-Aldrich syndrome protein to selective advantage in T- and B-cell lineages.
Somatic mosaicism because of in vivo reversion has been recently reported in a small number of patients affected with Wiskott… 
Highly Cited
2003
Highly Cited
2003
Functional correction of T cells derived from patients with the Wiskott–Aldrich syndrome (WAS) by transduction with an oncoretroviral vector encoding the WAS protein
T-cell dysfunction is thought to be central to the immunodeficiency state seen in patients with the Wiskott–Aldrich syndrome (WAS… 
Highly Cited
2002
Highly Cited
2002
Restoration of podosomes and chemotaxis in Wiskott-Aldrich syndrome macrophages following induced expression of WASp.
Highly Cited
2002
Highly Cited
2002
Retrovirus-mediated WASP gene transfer corrects Wiskott-Aldrich syndrome T-cell dysfunction.
The Wiskott-Aldrich syndrome (WAS) is an X-linked disorder characterized by thrombocytopenia, eczema, and immunodeficiency. At… 
Highly Cited
2001
Highly Cited
2001
Cdc42, Rac1, and the Wiskott-Aldrich syndrome protein are involved in the cytoskeletal regulation of B lymphocytes.
Patients with the immunodeficiency disorder Wiskott-Aldrich syndrome (WAS) have lymphocytes with aberrant microvilli, and their T… 
1990
1990
Linkage relationships of the Wiskott-Aldrich syndrome to 10 loci in the pericentromeric region of the human X chromosome.
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