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WAS gene

Known as: WASPA, WASP, Wiskott-Aldrich syndrome 
This gene is involved in signal transduction and plays a role in cell communication and organization.
National Institutes of Health

Related topics

Related topics

7 relations
Cytoskeletal ModelingSignal TransductionWAS protein, humanWAS wt Allele

Papers overview

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Highly Cited
2008
Highly Cited
2008
Wiskott-Aldrich syndrome protein deficiency in B cells results in impaired peripheral homeostasis
To more precisely identify the B-cell phenotype in Wiskott-Aldrich syndrome (WAS), we used 3 distinct murine in vivo models to… 
Highly Cited
2006
Highly Cited
2006
Efficacy of gene therapy for Wiskott-Aldrich syndrome using a WAS promoter/cDNA-containing lentiviral vector and nonlethal irradiation.
Wiskott-Aldrich syndrome (WAS) is a life-threatening X-linked primary immunodeficiency characterized by infections, hemorrhages… 
Highly Cited
2005
Highly Cited
2005
Defective nuclear translocation of nuclear factor of activated T cells and extracellular signal-regulated kinase underlies deficient IL-2 gene expression in Wiskott-Aldrich syndrome.
Highly Cited
2004
Highly Cited
2004
Differential contribution of Wiskott-Aldrich syndrome protein to selective advantage in T- and B-cell lineages.
Somatic mosaicism because of in vivo reversion has been recently reported in a small number of patients affected with Wiskott… 
Highly Cited
2003
Highly Cited
2003
Functional correction of T cells derived from patients with the Wiskott–Aldrich syndrome (WAS) by transduction with an oncoretroviral vector encoding the WAS protein
T-cell dysfunction is thought to be central to the immunodeficiency state seen in patients with the Wiskott–Aldrich syndrome (WAS… 
Highly Cited
2002
Highly Cited
2002
Restoration of podosomes and chemotaxis in Wiskott-Aldrich syndrome macrophages following induced expression of WASp.
Highly Cited
2001
Highly Cited
2001
Cdc42, Rac1, and the Wiskott-Aldrich syndrome protein are involved in the cytoskeletal regulation of B lymphocytes.
Patients with the immunodeficiency disorder Wiskott-Aldrich syndrome (WAS) have lymphocytes with aberrant microvilli, and their T… 
2000
2000
Structural basis of Wiskott-Aldrich syndrome causing mutations in the WH1 domain
Wiskott-Aldrich syndrome (WAS) is an X-linked recessive immunodeficiency disease associated with eczema, hemorrhagic episodes… 
Highly Cited
1999
Highly Cited
1999
The thrombocytopenia of Wiskott Aldrich syndrome is not related to a defect in proplatelet formation.
The Wiskott-Aldrich syndrome (WAS) is an X-linked hereditary disease characterized by thrombocytopenia with small platelet size… 
1990
1990
Linkage relationships of the Wiskott-Aldrich syndrome to 10 loci in the pericentromeric region of the human X chromosome.
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