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Contact Inhibition of Locomotion in vivo controls neural crest directional migration
Contact inhibition of locomotion was discovered by Abercrombie more than 50 years ago and describes the behaviour of fibroblast cells confronting each other in vitro, where they retract theirExpand
Arp2/3 complex interactions and actin network turnover in lamellipodia
Cell migration is initiated by lamellipodia—membrane‐enclosed sheets of cytoplasm containing densely packed actin filament networks. Although the molecular details of network turnover remain obscure,Expand
Role of vinculin in regulating focal adhesion turnover.
Although vinculin (-/-) mouse embryo fibroblasts assemble focal adhesions (FAs), they spread more slowly, less extensively, and close a wound more rapidly than vinculin (+/+) cells. To investigateExpand
Alignment of fibroblasts on grooved surfaces described by a simple geometric transformation.
The response of chick heart fibroblasts to grooved substrata was studied using microfabricated grooves and new measures of shape and alignment derived from the moments of cell shapes. Cell shape andExpand
A new direct-viewing chemotaxis chamber.
A new form of chamber for studying chemotaxis, similar in principle to the Zigmond chamber, allows the behaviour of the cells in a linear concentration gradient to be observed directly. The chamberExpand
Inter-Cellular Forces Orchestrate Contact Inhibition of Locomotion
Summary Contact inhibition of locomotion (CIL) is a multifaceted process that causes many cell types to repel each other upon collision. During development, this seemingly uncoordinated reaction is aExpand
Clasp-mediated microtubule bundling regulates persistent motility and contact repulsion in Drosophila macrophages in vivo
A microtubule arm regulates cell–cell repulsion, pointing hemocytes in opposite directions when they contact each other in Drosophila embryos.
A new hypothesis of contact guidance in tissue cells.
Abstract The reaction of chick heart fibroblasts to the curvature of cylindrical substrata was assessed using a measure based on the ratio of nuclear dimensions along and across the axis of theExpand
A Unified Approach to Analysing Cell Motility
SUMMARY The quantitative analysis of cell motility in culture has several important functions. First, it gives a concise and accurate description of the motile process and can detect subtleExpand
PTEN couples Sema3A signalling to growth cone collapse
Distinct changes in glycogen synthase kinase-3 (GSK-3) signalling can regulate neuronal morphogenesis including the determination and maintenance of axonal identity, and are required forExpand