VX-970

Known as: ATR Kinase Inhibitor VX-970 
An inhibitor of ataxia telangiectasia and rad3-related (ATR) kinase, a DNA damage response kinase, with potential antineoplastic activity. ATR kinase… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

2014-2018
01220142018

Papers overview

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2018
2018
BACKGROUND M6620 is a novel inhibitor of the DNA damage repair enzyme ATR, and has potentiated the activity of cisplatin and… (More)
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2017
2017
DNA damaging chemotherapy and radiation are widely used standard-of-care modalities for the treatment of cancer. Nevertheless… (More)
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2017
2017
BACKGROUND For a clinical trials unit to run its first model-based, phase I trial, the statistician, chief investigator, and… (More)
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2017
2017
Purpose Our preclinical work identified depletion of ATR as a top candidate for topoisomerase 1 (TOP1) inhibitor synthetic… (More)
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2017
2017
Vertex Pharmaceuticals, the Boston-based biotech known for developing novel cystic fibrosis drugs, has licensed four R&D cancer… (More)
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2016
2016
BACKGROUND AND PURPOSE Esophageal cancer has a persistently low 5-year survival rate and has recently been classified as a cancer… (More)
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Review
2015
Review
2015
In this article, we review the ATR inhibitor field from initial pharmacological tools to first-generation clinical candidates… (More)
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Review
2015
Review
2015
The human ATR gene encodes a kinase that is activated by DNA damage and replication stress as a central transducer of a… (More)
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2014
2014
Platinum-based DNA-damaging chemotherapy is standard-of-care for most patients with lung cancer but outcomes remain poor. This… (More)
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2014
2014
Camptothecin and its derivatives, topotecan and irinotecan, are specific topoisomerase I (Top1) inhibitors and potent anticancer… (More)
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