VU0364572

 
National Institutes of Health

Topic mentions per year

Topic mentions per year

2011-2018
0120112018

Papers overview

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2018
2018
Alzheimer's disease (AD) is a neurodegenerative disease that disproportionately impacts memory and the hippocampus. However, it… (More)
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2017
2017
Alzheimer's disease (AD) is the leading cause of dementia worldwide, and currently no disease-modifying therapy is available to… (More)
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2016
2016
The muscarinic M1 acetylcholine receptor is a key target for drugs aimed at treating cognitive dysfunction, including the memory… (More)
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2014
2014
Acetylcholine signaling through muscarinic receptors has been shown to benefit memory performance in some conditions, but pan… (More)
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2012
2012
We previously reported the discovery of VU0364572 and VU0357017 as M(1)-selective agonists that appear to activate M(1) through… (More)
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2012
2012
M(1) muscarinic acetylcholine receptors (mAChRs) represent a viable target for treatment of multiple disorders of the central… (More)
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2011
2011
Herein we report the discovery and SAR of a novel series of M(1) agonists based on the MLPCN probe, ML071. From this, VU0364572… (More)
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