VKORC1 gene

Known as: Vitamin K Epoxide Reductase Complex, Subunit 1 Gene, VKORC1, VKOR 
This gene is involved in blood clotting via the enzymatic activation of Vitamin K.
National Institutes of Health

Topic mentions per year

Topic mentions per year

1997-2018
05019972018

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2010
Highly Cited
2010
Warfarin-dosing algorithms incorporating CYP2C9 and VKORC1 -1639G>A improve dose prediction compared with algorithms based solely… (More)
  • table 1
  • table 2
  • table 3
  • table 4
  • figure 1
Is this relevant?
Highly Cited
2009
Highly Cited
2009
We report the first genome-wide association study (GWAS) whose sample size (1,053 Swedish subjects) is sufficiently powered to… (More)
  • figure 1
  • table 1
  • table 2
  • table 3
Is this relevant?
Highly Cited
2006
Highly Cited
2006
OBJECTIVE To investigate pharmacokinetic and pharmacodynamic factors associated with population differences in warfarin doses… (More)
  • table 1
  • figure 1
  • table 2
  • figure 2
  • figure 3
Is this relevant?
Highly Cited
2005
Highly Cited
2005
BACKGROUND The management of warfarin therapy is complicated by a wide variation among patients in drug response. Variants in the… (More)
  • figure 1
  • table 1
  • table 2
  • figure 2
Is this relevant?
Highly Cited
2005
Highly Cited
2005
Patients require different warfarin dosages to achieve the target therapeutic anticoagulation. The variability is largely… (More)
  • table 1
  • table 2
  • table 3
  • table 4
Is this relevant?
Highly Cited
2005
Highly Cited
2005
Current dosing algorithms do not account for genetic and environmental factors for warfarin dose determinations. This study… (More)
  • table 1
  • table 2
  • table 3
  • figure 1
  • figure 2
Is this relevant?
Highly Cited
2005
Highly Cited
2005
We report a novel combination of factors that explains almost 60% of variable response to warfarin. Warfarin is a widely used… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2005
Highly Cited
2005
The aim of the study is to explore the contribution of genetic factors related either to drug metabolism (cytochrome P450 2C9) or… (More)
  • table 1
  • figure 1
  • table 2
  • table 3
  • table 4
Is this relevant?
Highly Cited
2005
Highly Cited
2005
Warfarin, a commonly prescribed anticoagulant, exhibited large inter-individual and inter-ethnic differences in the dose required… (More)
  • table 1
  • figure 1
  • table 2
  • table 3
  • figure 2
Is this relevant?
Highly Cited
2004
Highly Cited
2004
Coumarin derivatives such as warfarin represent the therapy of choice for the long-term treatment and prevention of… (More)
Is this relevant?