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VKORC1 gene

Known as: Vitamin K Epoxide Reductase Complex, Subunit 1 Gene, VKORC1, VKOR 
This gene is involved in blood clotting via the enzymatic activation of Vitamin K.
National Institutes of Health

Related topics

Related topics

4 relations
Blood coagulationOxidation-ReductionVKORC1L1 geneVitamin K Epoxide Reductase Complex, Subunit 1

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2012
2012
Human Vitamin K Epoxide Reductase and Its Bacterial Homologue Have Different Membrane Topologies and Reaction Mechanisms*♦
Background: The membrane topology and the role of certain cysteines in human vitamin K epoxide reductase (VKOR) are disputed… 
2012
2012
Analysis of CYP2C9*2, CYP2C9*3 and VKORC1 -1639 G>A polymorphisms in a population from South-Eastern Europe
The CYP2C9 enzyme metabolizes a wide range of relevant drugs, among which are oral anticoagulants. VKORC1 is the pharmacodynamic… 
Highly Cited
2010
Highly Cited
2010
A regression model to predict warfarin dose from clinical variables and polymorphisms in CYP2C9, CYP4F2, and VKORC1: Derivation in a sample with predominantly a history of venous thromboembolism.
Highly Cited
2009
Highly Cited
2009
Relative contribution of CYP2C9 and VKORC1 genotypes and early INR response to the prediction of warfarin sensitivity during initiation of therapy.
Genetic variants in CYP2C9 and VKORC1 strongly affect steady-state warfarin dose. However, these variants also affect early… 
Review
2008
Review
2008
Structure and function of vitamin K epoxide reductase.
Highly Cited
2007
Highly Cited
2007
Genotypes of vitamin K epoxide reductase, gamma-glutamyl carboxylase, and cytochrome P450 2C9 as determinants of daily warfarin dose in Japanese patients.
Review
2007
Review
2007
Current pharmacogenetic developments in oral anticoagulation therapy: The influence of variant VKORC1 and CYP2C9 alleles
Summary For decades coumarins have been the most commonly prescribed drugs for therapy and prophylaxis of thromboembolic… 
2006
2006
r-VKORC1 expression in factor IX BHK cells increases the extent of factor IX carboxylation but is limited by saturation of another carboxylation component or by a shift in the rate-limiting step.
Carboxylation of vitamin K-dependent (VKD) proteins is required for their activity and depends on reduced vitamin K generated by… 
2005
2005
Engineering of a recombinant vitamin K-dependent gamma-carboxylation system with enhanced gamma-carboxyglutamic acid forming capacity: evidence for a functional CXXC redox center in the system.
The vitamin K-dependent gamma-carboxylation system in the endoplasmic reticulum membrane responsible for gamma-carboxyglutamic… 
Highly Cited
1998
Highly Cited
1998
Warfarin Resistance Is Associated with a Protein Component of the Vitamin K 2,3-Epoxide Reductase Enzyme Complex in Rat Liver
Summary Warfarin, the most used drug in the world in long-term anticoagulation prophylaxis, targets the vitamin K 2,3-epoxide… 
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