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VKORC1 gene

Known as: Vitamin K Epoxide Reductase Complex, Subunit 1 Gene, VKORC1, VKOR 
This gene is involved in blood clotting via the enzymatic activation of Vitamin K.
National Institutes of Health

Related topics

Related topics

4 relations
Blood coagulationOxidation-ReductionVKORC1L1 geneVitamin K Epoxide Reductase Complex, Subunit 1

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Reoxidation of the Thiol-Disulfide Oxidoreductase MdbA by a Bacterial Vitamin K Epoxide Reductase in the Biofilm-Forming Actinobacterium Actinomyces oris
ABSTRACT Posttranslocational protein folding in the Gram-positive biofilm-forming actinobacterium Actinomyces oris is mediated by… 
2014
2014
Nutri-pharmacogenomics of warfarin anticoagulation therapy: VKORC1 genotype-dependent influence of dietary vitamin K intake
Warfarin is the most widely prescribed oral anticoagulant, but large interindividual variations exist in the dose required to… 
Review
2011
Review
2011
Clinical significance of combined CYP2C9 and VKORC1 genotypes in Japanese patients requiring warfarin.
The individual management of anticoagulation therapy is important for safe medical outcomes, including those of oral surgery… 
2010
2010
Distribution of CYP2C9 and VKORC1 risk alleles for warfarin sensitivity and resistance in the Israeli population.
PURPOSE This study was designed to delineate the relative frequency of CYP2C9 and VKORC1 polymorphisms known to affect warfarin… 
2010
2010
An evaluation of nine genetic variants related to metabolism and mechanism of action of warfarin as applied to stable dose prediction
Warfarin anticoagulation is complicated by the highly variable inter-individual response. Approximately 50% of the dose… 
2009
2009
Prevalence of combinatorial CYP2C9 and VKORC1 genotypes in Puerto Ricans: implications for warfarin management in Hispanics.
Polymorphisms in the cytochrome P450 2C9 (CYP2C9) and vitamin K epoxide reductase complex subunit 1 (VKORC1) genes significantly… 
2009
2009
SYBR Green-based real-time PCR assay for detection of VKORC1 and CYP2C9 polymorphisms that modulate warfarin dose requirement
Abstract Background: Polymorphisms in VKORC1 (vitamin K epoxide reductase complex subunit 1) and CYP2C9 (cytochrome P450 2C9… 
2006
2006
r-VKORC1 expression in factor IX BHK cells increases the extent of factor IX carboxylation but is limited by saturation of another carboxylation component or by a shift in the rate-limiting step.
Carboxylation of vitamin K-dependent (VKD) proteins is required for their activity and depends on reduced vitamin K generated by… 
2006
2006
Heterogeneity of the coumarin anticoagulant targeted vitamin K epoxide reduction system. Study of kinetic parameters in susceptible and resistant mice (Mus musculus domesticus)
Vitamin K epoxide reductase (VKOR) activity in liver microsomes from a susceptible and a genetically warfarin‐resistant strain of… 
2005
2005
Vitamin K Epoxide Reductase: A Protein Involved in Angiogenesis
Vitamin K epoxide reductase (VKOR) is a newly identified protein which has been reported to convert the epoxide of vitamin K back… 
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