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Vitamin K Epoxide Reductase Complex, Subunit 1
Known as:
Vitamin K1 2,3-Epoxide Reductase Subunit 1
, VKORC1
, VKORC1 Protein
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Vitamin K epoxide reductase complex subunit 1 (163 aa, ~18 kDa) is encoded by the human VKORC1 gene. The protein is an integral membrane protein that…
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National Institutes of Health
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Related topics
Related topics
5 relations
Enzyme Gene
Homo sapiens
Oxidation-Reduction
Oxidoreductase Gene
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Review
2013
Review
2013
Genetic and Clinical Determinants Influencing Warfarin Dosing in Children With Heart Disease
Nguyenvu Nguyen
,
P. Anley
,
Margaret Yu
,
Gang Zhang
,
A. Thompson
,
L. Jennings
Pediatric Cardiology
2013
Corpus ID: 23242551
Warfarin is a common anticoagulant with narrow therapeutic window and variable anticoagulation effects. Single gene polymorphisms…
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Review
2013
Review
2013
Expanding Role of Pharmacogenomics in the Management of Cardiovascular Disorders
V. Yip
,
M. Pirmohamed
American Journal of Cardiovascular Drugs
2013
Corpus ID: 7190903
Cardiovascular disease is a leading cause of death worldwide. Many pharmacologic therapies are available that aim to reduce the…
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2010
2010
Comparison of assay systems for warfarin-related CYP2C9 and VKORC1 genotyping.
Carleta B Maurice
,
Pankaj K. Barua
,
Diane Simses
,
Penny Smith
,
J. Howe
,
G. Stack
Clinica chimica acta; international journal of…
2010
Corpus ID: 38166530
2010
2010
Genotype polymorphisms of GGCX, NQO1, and VKORC1 genes associated with risk susceptibility in patients with large-artery atherosclerotic stroke.
H. Shyu
,
C. Fong
,
+5 authors
Chun‐Wen Cheng
Clinica chimica acta; international journal of…
2010
Corpus ID: 38281118
2010
2010
A bimodular oxidoreductase mediates the specific reduction of phylloquinone (vitamin K₁) in chloroplasts.
F. Furt
,
Chloë van Oostende
,
Joshua R. Widhalm
,
Matthew A. Dale
,
J. Wertz
,
G. Basset
The Plant Journal
2010
Corpus ID: 24471247
Plants and certain species of cyanobacteria are the only organisms capable of synthesizing phylloquinone (vitamin K₁ for…
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2009
2009
Comparison of performance of three commercial platforms for warfarin sensitivity genotyping.
N. Babic
,
Eden V. Haverfield
,
Julie A Burrus
,
A. Lozada
,
Soma Das
,
K. Yeo
Clinica chimica acta; international journal of…
2009
Corpus ID: 27702470
2008
2008
Enhanced functional recombinant factor VII production by HEK 293 cells stably transfected with VKORC1 where the gamma-carboxylase inhibitor calumenin is stably suppressed by shRNA transfection.
N. Wajih
,
J. Owen
,
R. Wallin
Thrombosis Research
2008
Corpus ID: 21434602
2007
2007
Comparison of the inhibition effect of different anticoagulants on vitamin K epoxide reductase activity from warfarin-susceptible and resistant rat
R. Lasseur
,
A. Grandemange
,
C. Longin‐Sauvageon
,
P. Berny
,
E. Benoît
2007
Corpus ID: 13412822
2006
2006
1173C>T Polymorphism in VKORC1 Modulates the Required Warfarin Dose
K. Kosaki
,
C. Yamaghishi
,
+9 authors
T. Takahashi
Pediatric Cardiology
2006
Corpus ID: 1317819
The response to warfarin is highly variable among individuals and such variability is likely to have some genetic basis. We…
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2006
2006
Genetic polymorphism of vitamin K epoxide reductase (VKORC1) 1173C>T in a Chinese and a Caucasian population.
C. Larramendy-Gozalo
,
J. Yang
,
+7 authors
L. Becquemont
Basic & Clinical Pharmacology & Toxicology
2006
Corpus ID: 40697066
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