Vitamin K Epoxide Reductase Complex, Subunit 1

Known as: Vitamin K1 2,3-Epoxide Reductase Subunit 1, VKORC1, VKORC1 Protein 
Vitamin K epoxide reductase complex subunit 1 (163 aa, ~18 kDa) is encoded by the human VKORC1 gene. The protein is an integral membrane protein that… (More)
National Institutes of Health

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Enzyme GeneHomo sapiensOxidation-ReductionOxidoreductase Gene
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Papers overview

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2014
2014
Conserved loop cysteines of vitamin K epoxide reductase complex subunit 1-like 1 (VKORC1L1) are involved in its active site regeneration.
Vitamin K epoxide reductase complex subunit 1 (VKORC1) reduces vitamin K epoxide in the vitamin K cycle for post-translational… (More)
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2013
2013
Determination of the warfarin inhibition constant Ki for vitamin K 2,3-epoxide reductase complex subunit-1 (VKORC1) using an in vitro DTT-driven assay.
BACKGROUND Warfarin directly inhibits vitamin K 2,3-epoxide reductase (VKOR) enzymes. Since the early 1970s, warfarin inhibition… (More)
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2012
2012
miR-133a regulates vitamin K 2,3-epoxide reductase complex subunit 1 (VKORC1), a key protein in the vitamin K cycle.
Regulation of key proteins by microRNAs (miRNAs) is an emergent field in biomedicine. Vitamin K 2,3-epoxide reductase complex… (More)
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2012
2012
Human herpesvirus 8 viral interleukin-6 interacts with splice variant 2 of vitamin K epoxide reductase complex subunit 1.
Viral interleukin-6 (vIL-6) specified by human herpesvirus 8 is, unlike its cellular counterpart, secreted very inefficiently and… (More)
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2008
2008
Vitamin K epoxide reductase complex subunit 1 (VKORC1) polymorphism and aortic calcification: the Rotterdam Study.
OBJECTIVE Besides effects on hemostasis, vitamin K-dependent proteins play a role in bone mineralization and arterial… (More)
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Review
2006
Review
2006
Vitamin K epoxide reductase complex subunit 1 (VKORC1): the key protein of the vitamin K cycle.
Vitamin K epoxide, a by-product of the carboxylation of blood coagulation factors, is reduced to vitamin K by an enzymatic system… (More)
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Highly Cited
2005
Highly Cited
2005
Cytochrome P450 2C9 (CYP2C9) and vitamin K epoxide reductase (VKORC1) genotypes as determinants of acenocoumarol sensitivity.
The aim of the study is to explore the contribution of genetic factors related either to drug metabolism (cytochrome P450 2C9) or… (More)
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Highly Cited
2005
Highly Cited
2005
Association of Vitamin K epoxide reductase complex 1 (VKORC1) variants with warfarin dose in a Hong Kong Chinese patient population.
OBJECTIVE To evaluate the association of VKORC1 genetic variants with warfarin dose requirements in a Hong Kong Chinese patient… (More)
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Highly Cited
2005
Highly Cited
2005
The impact of CYP2C9 and VKORC1 genetic polymorphism and patient characteristics upon warfarin dose requirements: proposal for a new dosing regimen.
Current dosing algorithms do not account for genetic and environmental factors for warfarin dose determinations. This study… (More)
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Highly Cited
2004
Highly Cited
2004
Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2
Coumarin derivatives such as warfarin represent the therapy of choice for the long-term treatment and prevention of… (More)
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