Comparison of assay systems for warfarin-related CYP2C9 and VKORC1 genotyping.

@article{Maurice2010ComparisonOA,
  title={Comparison of assay systems for warfarin-related CYP2C9 and VKORC1 genotyping.},
  author={Carleta B Maurice and Pankaj K Barua and Diane Simses and Penny M. C. Smith and John Greg Howe and Gary E Stack},
  journal={Clinica chimica acta; international journal of clinical chemistry},
  year={2010},
  volume={411 13-14},
  pages={947-54}
}
BACKGROUND A variety of commercial genotyping assays is available to detect variants in the CYP2C9 and VKORC1 genes. The assay results are used in genotype-based warfarin dosing algorithms. We compared the performance of four such assay systems: Verigene, eSensor, Invader, and Luminex. METHODS Result concordance and no call rates were determined on patient specimens tested on all four instruments. Turnaround times (TAT), hands-on time (HOT), pipetting steps and cost were obtained for runs of… CONTINUE READING

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