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UniPR129

 
National Institutes of Health

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3 relations

Broader (2)

Lithocholic AcidTryptophan
analogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2020
2020
Evaluation of the Anti-Tumor Activity of Small Molecules Targeting Eph/Ephrins in APC min/J Mice.
The Eph receptors are the largest receptors tyrosine kinases (RTKs) family in humans and together with ephrin ligands constitute… Expand
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2018
2018
Pharmacological evaluation of new bioavailable small molecules targeting Eph/ephrin interaction
ABSTRACT Eph/ephrin system is an emerging target for cancer therapy but the lack of potent, stable and orally bioavailable… Expand
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2017
2017
Metadynamics for Perspective Drug Design: Computationally Driven Synthesis of New Protein-Protein Interaction Inhibitors Targeting the EphA2 Receptor.
Metadynamics (META-D) is emerging as a powerful method for the computation of the multidimensional free-energy surface (FES… Expand
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2015
2015
Comparative Analysis of Virtual Screening Approaches in the Search for Novel EphA2 Receptor Antagonists
The EphA2 receptor and its ephrin-A1 ligand form a key cell communication system, which has been found overexpressed in many… Expand
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2015
2015
EPH receptor/ephrin system: in the quest for novel anti-angiogenic therapies: Commentary on Hassan-Mohamed et al., Br J Pharmacol 171: 5195-5208.
LINKED ARTICLE This article is a Commentary on Hassan-Mohamed I, Giorgio C, Incerti M, Russo S, Pala D, Pasquale EB, Zanotti I… Expand
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2014
2014
UniPR129 is a competitive small molecule Eph-ephrin antagonist blocking in vitro angiogenesis at low micromolar concentrations.
BACKGROUND AND PURPOSE The Eph receptor tyrosine kinases and their ephrin ligands are key players in tumorigenesis and many… Expand
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2014
2014
Eph/ephrin sytem: In the quest of novel anti-angiogenic therapies.
 
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