FAQ

Ubiquitin-mediated Proteolysis Pathway

Known as: Ubiquitin-mediated Proteolysis 
Protein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1990-2017
02419902017

Related topics

Related topics

50 relations
AIRE protein, humanCBLB protein, humanCBLC wt AlleleCUL4B wt Allele
(More)

Related mentions per year

Related mentions per year

1940-2018
1960198020002020
Ubiquitin-mediated Proteolysis Pathway
VHL protein, human
Skp2 Proteins
FBXW7 protein, human
UBE3A wt Allele
Cullin 1

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
The hypoxia-responsive lncRNA NDRG-OT1 promotes NDRG1 degradation via ubiquitin-mediated proteolysis in breast cancer cells
Hypoxia can lead to solid tumor aggressiveness by driving multiple signaling pathways. Long non-coding RNAs respond to several… (More)
  • figure 1
  • figure 2
  • table 1
  • figure 3
  • table 2
Is this relevant?
2016
2016
Regulatory mechanisms underlying sepsis progression in patients with tumor necrosis factor-α genetic variations.
The present study aimed to investigate the regulatory mechanisms underlying sepsis progression in patients with tumor necrosis… (More)
Is this relevant?
Highly Cited
2011
Highly Cited
2011
Frequent mutations of genes encoding ubiquitin-mediated proteolysis pathway components in clear cell renal cell carcinoma
We sequenced whole exomes of ten clear cell renal cell carcinomas (ccRCCs) and performed a screen of ∼1,100 genes in 88… (More)
Is this relevant?
2008
2008
SCFCdc4 acts antagonistically to the PGC-1alpha transcriptional coactivator by targeting it for ubiquitin-mediated proteolysis.
Peroxisome proliferator-activated receptor gamma (PPARgamma) coactivator-1alpha (PGC-1alpha) is a highly regulated… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
2008
2008
SCF acts antagonistically to the PGC-1 transcriptional coactivator by targeting it for ubiquitin-mediated proteolysis
Peroxisome proliferator-activated receptor (PPAR ) coactivator-1 (PGC-1 ) is a highly regulated transcriptional coactivator that… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2008
Highly Cited
2008
GSK-3 beta targets Cdc25A for ubiquitin-mediated proteolysis, and GSK-3 beta inactivation correlates with Cdc25A overproduction in human cancers.
The Cdc25A phosphatase positively regulates cell-cycle transitions, is degraded by the proteosome throughout interphase and in… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2003
Highly Cited
2003
Regulation of NF-kappaB signaling by Pin1-dependent prolyl isomerization and ubiquitin-mediated proteolysis of p65/RelA.
The transcription factor NF-kappaB is activated by the degradation of its inhibitor IkappaBalpha, resulting in its nuclear… (More)
Is this relevant?
Review
2003
Review
2003
Role of ubiquitin-mediated proteolysis in the pathogenesis of neurodegenerative disorders.
Intraneuronal inclusions containing ubiquitylated filamentous protein aggregates are a common feature of many of the major human… (More)
Is this relevant?
Highly Cited
1999
Highly Cited
1999
Destruction of Myc by ubiquitin-mediated proteolysis: cancer-associated and transforming mutations stabilize Myc.
The human proto-oncogene c-myc encodes a highly unstable transcription factor that promotes cell proliferation. Although the… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
1993
1993
Ubiquitin pools, ubiquitin mRNA levels, and ubiquitin-mediated proteolysis in aging human fibroblasts.
Senescent cells have less free ubiquitin and more ubiquitin-protein conjugates than do young cells. The ubiquitin-protein… (More)
Is this relevant?