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Ubiquitin-Protein Ligase Complexes

Known as: Ligase Complexes, Ubiquitin-Protein, Ubiquitin Protein Ligase, Complexes, Ubiquitin-Protein Ligase 
Complexes of enzymes that catalyze the covalent attachment of UBIQUITIN to other proteins by forming a peptide bond between the C-terminal GLYCINE of… Expand
National Institutes of Health

Related topics

Related topics

49 relations
BTB/POZ Domain-Containing Adapter For CUL3-Mediated RhoA Degradation Protein 2CBLB protein, humanCCNB1IP1 protein, humanCullin 1
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Narrower (5)

CRL4(Cdt2) protein, XenopusNEURL2 protein, humanPIB1 protein, S cerevisiaeRSP5 protein, S cerevisiae
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Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
MAGEA1 interacts with FBXW7 and regulates ubiquitin ligase-mediated turnover of NICD1 in breast and ovarian cancer cells
Melanoma-associated antigen A1 (MAGEA1) is member of the MAGE gene family that is expressed in male germ line cells and placenta… Expand
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2013
2013
Structural basis of intersubunit recognition in elongin BC-cullin 5-SOCS box ubiquitin-protein ligase complexes.
  • Y. Kim, M. Kwak, +5 authors B. Oh
  • Acta crystallographica. Section D, Biological…
  • 2013
    • Corpus ID: 1710105
The cullin-RING ubiquitin ligases are multisubunit complexes that ubiquitinate various proteins. Six different cullins encoded by… Expand
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2012
2012
Rapamycin resistance is linked to defective regulation of Skp2.
The mammalian target of rapamycin (mTOR) plays a role in controlling malignant cellular growth. mTOR inhibitors, including… Expand
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Review
2008
Review
2008
Emerging roles of S-nitrosylation in protein misfolding and neurodegenerative diseases.
Overactivation of N-methyl-D-aspartate (NMDA)-type glutamate receptors accounts, at least in part, for excitotoxic neuronal… Expand
Highly Cited
2007
Highly Cited
2007
Human placental hypoxia-inducible factor-1alpha expression correlates with clinical outcomes in chronic hypoxia in vivo.
Placental hypoxia is causally implicated in fetal growth restriction and preeclampsia, with both occurring more frequently at… Expand
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Highly Cited
2006
Highly Cited
2006
Regulation of neddylation and deneddylation of cullin1 in SCFSkp2 ubiquitin ligase by F-box protein and substrate.
The activity of cullin-containing ubiquitin protein ligase complexes is stimulated by linkage to cullin of the ubiquitin-like… Expand
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2004
2004
Functional analysis of the spindle-checkpoint proteins using an in vitro ubiquitination assay.
  • Z. Tang, H. Yu
  • Methods in molecular biology
  • 2004
    • Corpus ID: 20709452
The spindle checkpoint helps to ensure the fidelity of chromosome segregation during mitosis and meiosis. In response to sister… Expand
Highly Cited
2003
Highly Cited
2003
BTB proteins as henchmen of Cul3-based ubiquitin ligases
  • W. Krek
  • Nature Cell Biology
  • 2003
    • Corpus ID: 22334493
The choice of ubiquitination substrates of Cul1- and Cul2-based E3 ubiquitin protein ligase complexes is dictated by the identity… Expand
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Highly Cited
1998
Highly Cited
1998
Association of human CUL‐1 and ubiquitin‐conjugating enzyme CDC34 with the F‐box protein p45SKP2: evidence for evolutionary conservation in the subunit composition of the CDC34–SCF pathway
In normal and transformed cells, the F‐box protein p45SKP2 is required for S phase and forms stable complexes with p19SKP1 and… Expand
Highly Cited
1997
Highly Cited
1997
The von Hippel-Lindau tumor-suppressor gene product forms a stable complex with human CUL-2, a member of the Cdc53 family of proteins.
The inactivation of the von Hippel-Lindau (VHL) gene predisposes affected individuals to VHL syndrome and is an early genetic… Expand
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