Skip to search formSkip to main contentSkip to account menu

USP8 gene

Known as: USP8, Ubiquitin Specific Protease 8 Gene, SPG59 
This gene plays a role in ubiquitin-dependent proteolysis and cell proliferation.
National Institutes of Health

Related topics

Related topics

6 relations
Cell ProliferationDeubiquitinationHydrolysisProteolysis

Narrower (1)

USP8 wt Allele

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2016
Highly Cited
2016
The USP8 mutational status may predict drug susceptibility in corticotroph adenomas of Cushing's disease.
CONTEXT Somatic mutations in the ubiquitin-specific peptidase USP8 gene were recently detected in one- to two-third(s) of… 
Highly Cited
2012
Highly Cited
2012
USP8 Promotes Smoothened Signaling by Preventing Its Ubiquitination and Changing Its Subcellular Localization
Hedgehog regulates the activity of its signal transducer Smoothened by enhancing its interaction with the deubiquitinase USP8… 
Highly Cited
2010
Highly Cited
2010
Regulation of Epidermal Growth Factor Receptor Ubiquitination and Trafficking by the USP8·STAM Complex*
Reversible ubiquitination of activated receptor complexes signals their sorting between recycling and degradation and thereby… 
Highly Cited
2009
Highly Cited
2009
Endosomal Deubiquitinating Enzymes Control Ubiquitination and Down-regulation of Protease-activated Receptor 2*
The E3 ubiquitin ligase c-Cbl ubiquitinates the G protein-coupled receptor protease-activated receptor 2 (PAR2), which is… 
Highly Cited
2006
Highly Cited
2006
The Ubiquitin Isopeptidase UBPY Regulates Endosomal Ubiquitin Dynamics and Is Essential for Receptor Down-regulation*
UBPY is a ubiquitin-specific protease that can deubiquitinate monoubiquitinated receptor tyrosine kinases, as well as process Lys… 
Highly Cited
2006
Highly Cited
2006
Amino-terminal Dimerization, NRDP1-Rhodanese Interaction, and Inhibited Catalytic Domain Conformation of the Ubiquitin-specific Protease 8 (USP8)*
Ubiquitin-specific protease 8 (USP8) hydrolyzes mono and polyubiquitylated targets such as epidermal growth factor receptors and… 
Highly Cited
2006
Highly Cited
2006
A Deubiquitinating Enzyme UBPY Regulates the Level of Protein Ubiquitination on Endosomes
Monoubiquitination of endocytosed cell surface receptors serves as a sorting signal for their trafficking from endosomes to… 
Highly Cited
2004
Highly Cited
2004
Stabilization of the E3 Ubiquitin Ligase Nrdp1 by the Deubiquitinating Enzyme USP8
ABSTRACT Nrdp1 is a RING finger-containing E3 ubiquitin ligase that physically interacts with and regulates steady-state cellular… 
Highly Cited
2000
Highly Cited
2000
A Deubiquitinating Enzyme UBPY Interacts with the Src Homology 3 Domain of Hrs-binding Protein via a Novel Binding Motif PX(V/I)(D/N)RXXKP*
Hrs-binding protein (Hbp) is a Src homology 3 (SH3) domain-containing protein that tightly associates with Hrs. Hbp together with… 
Highly Cited
1998
Highly Cited
1998
UBPY: a growth‐regulated human ubiquitin isopeptidase
The ubiquitin pathway has been implicated in the regulation of the abundance of proteins that control cell growth and… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)