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USP8 wt Allele

Known as: HumORF8, KIAA0055, HUMORF8 Gene 
Human USP8 wild-type allele is located in the vicinity of 15q21.2 and is approximately 75 kb in length. This allele, which encodes ubiquitin carboxyl… 
National Institutes of Health

Related topics

Related topics

9 relations
15q15.2Cell ProliferationDeubiquitinationERBB2/ERBB3 Signaling Pathway

Broader (1)

USP8 gene

Papers overview

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2015
2015
The Deubiquitinating Enzyme UBPY Is Required for Lysosomal Biogenesis and Productive Autophagy in Drosophila
Autophagy is a catabolic process that delivers cytoplasmic components to the lysosomes. Protein modification by ubiquitination is… 
Highly Cited
2010
Highly Cited
2010
Balanced ubiquitylation and deubiquitylation of Frizzled regulate cellular responsiveness to Wg/Wnt
Wingless (Wg)/Wnt has been proposed to exert various functions as a morphogen depending on the levels of its signalling… 
Highly Cited
2009
Highly Cited
2009
Endosomal Deubiquitinating Enzymes Control Ubiquitination and Down-regulation of Protease-activated Receptor 2*
The E3 ubiquitin ligase c-Cbl ubiquitinates the G protein-coupled receptor protease-activated receptor 2 (PAR2), which is… 
2008
2008
Dynamic regulation of ubiquitylation and deubiquitylation at the central spindle during cytokinesis
During cytokinesis, the central spindle, a bundle of interdigitated anti-parallel microtubules between separating chromosomes… 
Highly Cited
2006
Highly Cited
2006
The Ubiquitin Isopeptidase UBPY Regulates Endosomal Ubiquitin Dynamics and Is Essential for Receptor Down-regulation*
UBPY is a ubiquitin-specific protease that can deubiquitinate monoubiquitinated receptor tyrosine kinases, as well as process Lys… 
Highly Cited
2006
Highly Cited
2006
Degradation of Endocytosed Epidermal Growth Factor and Virally Ubiquitinated Major Histocompatibility Complex Class I Is Independent of Mammalian ESCRTII*
Models for protein sorting at multivesicular bodies in the endocytic pathway of mammalian cells have relied largely on data… 
Highly Cited
2006
Highly Cited
2006
A Deubiquitinating Enzyme UBPY Regulates the Level of Protein Ubiquitination on Endosomes
Monoubiquitination of endocytosed cell surface receptors serves as a sorting signal for their trafficking from endosomes to… 
Highly Cited
2001
Highly Cited
2001
Cloning and Characterization of Mouse UBPy, a Deubiquitinating Enzyme That Interacts with the Ras Guanine Nucleotide Exchange Factor CDC25Mm/Ras-GRF1*
We used yeast “two-hybrid” screening to isolate cDNA-encoding proteins interacting with the N-terminal domain of the Ras… 
Highly Cited
2000
Highly Cited
2000
A Deubiquitinating Enzyme UBPY Interacts with the Src Homology 3 Domain of Hrs-binding Protein via a Novel Binding Motif PX(V/I)(D/N)RXXKP*
Hrs-binding protein (Hbp) is a Src homology 3 (SH3) domain-containing protein that tightly associates with Hrs. Hbp together with… 
Highly Cited
1998
Highly Cited
1998
UBPY: a growth‐regulated human ubiquitin isopeptidase
The ubiquitin pathway has been implicated in the regulation of the abundance of proteins that control cell growth and… 
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