Skip to search formSkip to main contentSkip to account menu

UGT2B7 gene

Known as: UDP Glucuronosyltransferase 2 Family, Polypeptide B7 Gene, UGT2B7, UGT2B9 
This gene plays a role in estrogen metabolism.
National Institutes of Health

Related topics

Related topics

3 relations
UGT2B7 protein, humanglycosylation

Narrower (1)

UGT2B7 wt Allele

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2012
2012
Re: CYP2D6 genotype and tamoxifen response in postmenopausal women with endocrine-responsive breast cancer: the Breast International Group 1-98 trial and Re: CYP2D6 and UGT2B7 genotype and risk of…
the role of common and rare genetic variation in CYP2D6 in determining response to tamoxifen therapy in women with breast cancer… 
Highly Cited
2010
Highly Cited
2010
Interactions between human UDP-glucuronosyltransferase (UGT) 2B7 and UGT1A enzymes.
Glucuronidation catalyzed by UDP-glucuronosyltransferase (UGT) enzymes is an important pathway in the metabolism of drugs as well… 
Highly Cited
2008
Highly Cited
2008
UGT2B7 promoter variant −840G>A contributes to the variability in hepatic clearance of morphine in patients with sickle cell disease
The purpose of the study was to determine if UDP‐glucuronosyltransferase (UGT) 2B7 allelic variants encoding for UGT2B7, primary… 
2008
2008
Hepatocyte nuclear factor-1 alpha is associated with UGT1A1, UGT1A9 and UGT2B7 mRNA expression in human liver
Experimental evidence suggests HNF1α regulates UGT expression. This study investigates (1) whether the variability in HNF1… 
Highly Cited
2007
Highly Cited
2007
Limited influence of UGT1A1*28 and no effect of UGT2B7*2 polymorphisms on UGT1A1 or UGT2B7 activities and protein expression in human liver microsomes.
AIMS UGT1A1 and UGT2B7 are enzymes that commonly contribute to drug glucuronidation. Since genetic factors have been suggested to… 
Highly Cited
2006
Highly Cited
2006
Metabolism and disposition of varenicline, a selective alpha4beta2 acetylcholine receptor partial agonist, in vivo and in vitro.
The metabolism and disposition of varenicline (7,8,9,10-tetrahydro-6,10-methano-6H-pyrazino[2,3-h][3]benzazepine), a partial… 
2006
2006
Multiple regression analysis of pharmacogenetic variability of carvedilol disposition in 54 healthy Japanese volunteers.
The aim of this study was to evaluate the pharmacogenetic variability in the disposition of carvedilol in the Japanese population… 
Highly Cited
2005
Highly Cited
2005
TRANS-3′-HYDROXYCOTININE O- AND N-GLUCURONIDATIONS IN HUMAN LIVER MICROSOMES
Trans-3′-hydroxycotinine is a major metabolite of nicotine in humans and is mainly excreted as O-glucuronide in smoker's urine… 
2002
2002
Inhibition and active sites of UDP-glucuronosyltransferases 2B7 and 1A1.
Two human UDP-glucuronosyltransferases (UGTs), UGT2B7 and UGT1A1, catalyze the glucuronidation of many endo- and xenobiotics… 
2000
2000
Nonsteroidal anti-inflammatory drugs and phenols glucuronidation in Caco-2 cells: identification of the UDP-glucuronosyltransferases UGT1A6, 1A3 and 2B7.
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)