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UGT2B7 gene

Known as: UDP Glucuronosyltransferase 2 Family, Polypeptide B7 Gene, UGT2B7, UGT2B9 
This gene plays a role in estrogen metabolism.
National Institutes of Health

Related topics

Related topics

3 relations
UGT2B7 protein, humanglycosylation

Narrower (1)

UGT2B7 wt Allele

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2012
2012
Protein quantification of UDP-glucuronosyltransferases 1A1 and 2B7 in human liver microsomes by LC-MS/MS and correlation with glucuronidation activities
The aims of this study were to quantify absolute protein levels of uridine 5′-diphosphate-glucuronosyltransferases (UGTs) 1A1 and… 
2012
2012
Re: CYP2D6 genotype and tamoxifen response in postmenopausal women with endocrine-responsive breast cancer: the Breast International Group 1-98 trial and Re: CYP2D6 and UGT2B7 genotype and risk of…
the role of common and rare genetic variation in CYP2D6 in determining response to tamoxifen therapy in women with breast cancer… 
2011
2011
The Imidazoacridinone Antitumor Drug, C-1311, Is Metabolized by Flavin Monooxygenases but Not by Cytochrome P450s
5-Diethylaminoethylamino-8-hydroxyimidazoacridinone (C-1311) is an antitumor agent that is also active against autoimmune… 
2008
2008
Hepatocyte nuclear factor-1 alpha is associated with UGT1A1, UGT1A9 and UGT2B7 mRNA expression in human liver
Experimental evidence suggests HNF1α regulates UGT expression. This study investigates (1) whether the variability in HNF1… 
Highly Cited
2007
Highly Cited
2007
Limited influence of UGT1A1*28 and no effect of UGT2B7*2 polymorphisms on UGT1A1 or UGT2B7 activities and protein expression in human liver microsomes.
AIMS UGT1A1 and UGT2B7 are enzymes that commonly contribute to drug glucuronidation. Since genetic factors have been suggested to… 
2007
2007
Carboxylic acid drug-induced DNA nicking in HEK293 cells expressing human UDP-glucuronosyltransferases: role of acyl glucuronide metabolites and glycation pathways.
Glucuronidation of carboxylic-acid-containing drugs can yield reactive acyl (ester-linked) glucuronide metabolites that are able… 
2007
2007
Inhibitory potential of nonsteroidal anti-inflammatory drugs on UDP-glucuronosyltransferase 2B7 in human liver microsomes
ObjectiveA number of nonsteroidal anti-inflammatory drugs (NSAIDs) are subject to glucuronidation in humans, and UDP… 
2006
2006
Multiple regression analysis of pharmacogenetic variability of carvedilol disposition in 54 healthy Japanese volunteers.
The aim of this study was to evaluate the pharmacogenetic variability in the disposition of carvedilol in the Japanese population… 
Highly Cited
2005
Highly Cited
2005
TRANS-3′-HYDROXYCOTININE O- AND N-GLUCURONIDATIONS IN HUMAN LIVER MICROSOMES
Trans-3′-hydroxycotinine is a major metabolite of nicotine in humans and is mainly excreted as O-glucuronide in smoker's urine… 
2003
2003
Glucuronidation of catechols by human hepatic, gastric, and intestinal microsomal UDP-glucuronosyltransferases (UGT) and recombinant UGT1A6, UGT1A9, and UGT2B7.
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