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Signatures of mutational processes in human cancer
It is shown that hypermutation localized to small genomic regions, ‘kataegis’, is found in many cancer types, and this results reveal the diversity of mutational processes underlying the development of cancer.
The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups
The results provide a novel molecular stratification of the breast cancer population, derived from the impact of somatic CNAs on the transcriptome, and identify novel subgroups with distinct clinical outcomes, which reproduced in the validation cohort.
The clonal and mutational evolution spectrum of primary triple-negative breast cancers
It is shown that understanding the biology and therapeutic responses of patients with TNBC will require the determination of individual tumour clonal genotypes, and for the first time in an epithelial tumour subtype, the relative abundance of clonal frequencies among cases representative of the population is determined.
Differential oestrogen receptor binding is associated with clinical outcome in breast cancer
It is found that drug-resistant cancers still recruit ER to the chromatin, but that ER binding is a dynamic process, with the acquisition of unique ER-binding regions in tumours from patients that are likely to relapse.
Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer
It is found that cancer cells had a loss of monoacetylated and trimethylated forms of histone H4 early and accumulated during the tumorigenic process, which is a common hallmark of human tumor cells.
The landscape of cancer genes and mutational processes in breast cancer
Strong correlations between mutation number, age at which cancer was diagnosed and cancer histological grade are found, and multiple mutational signatures are observed, including one present in about ten per cent of tumours characterized by numerous mutations of cytosine at TpC dinucleotides.
Landscape of somatic mutations in 560 breast cancer whole genome sequences
This analysis of all classes of somatic mutation across exons, introns and intergenic regions highlights the repertoire of cancer genes and mutational processes operative, and progresses towards a comprehensive account of the somatic genetic basis of breast cancer.
Molecular classification and molecular forecasting of breast cancer: ready for clinical application?
- J. Brenton, L. Carey, A. Ahmed, C. Caldas
- MedicineJournal of clinical oncology : official journal…
- 10 October 2005
Two main applications of expression profiling are critically reviewed; studies unraveling novel breast cancer classifications and those that aim to identify novel markers for prediction of clinical outcome.
The somatic mutation profiles of 2,433 breast cancers refines their genomic and transcriptomic landscapes
This study sequence 173 genes in 2,433 primary breast tumours that have copy number aberration, gene expression and long-term clinical follow-up data, and determines associations between mutations, driver CNA profiles, clinical-pathological parameters and survival.
MicroRNA expression profiling of human breast cancer identifies new markers of tumor subtype
This study represents the first integrated analysis of miRNA expression, mRNA expression and genomic changes in human breast cancer and may serve as a basis for functional studies of the role of miRNAs in the etiology of breast cancer.