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UDP-Glucuronosyltransferase 2B17

Known as: UGT2B17, EC 2.4.1.17, UDP-Glucuronyltransferase, Family 2, Beta-17 
UDP-glucuronosyltransferase 2B17 (530 aa, ~61 kDa) is encoded by the human UGT2B17 gene. This protein plays a role in the metabolism of steroids and… Expand
National Institutes of Health

Related topics

Related topics

12 relations
Carbohydrate MetabolismEnzyme GeneGlycosyltransferase GenePentose and Glucuronate Interconversions Pathway
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Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
Androgen and Estrogen Receptors in Breast Cancer Coregulate Human UDP-Glucuronosyltransferases 2B15 and 2B17.
Glucuronidation is an enzymatic process that terminally inactivates steroid hormones, including estrogens and androgens, thereby… Expand
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2013
2013
The effect of copy number variation in the phase II detoxification genes UGT2B17 and UGT2B28 on colorectal cancer risk
Genetic polymorphisms in combination with the Western‐style diet, physical inactivity, smoking, excessive alcohol consumption… Expand
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Highly Cited
2010
Highly Cited
2010
Characterization of 17-dihydroexemestane glucuronidation: potential role of the UGT2B17 deletion in exemestane pharmacogenetics
Objective Exemestane is a third-generation aromatase inhibitor used in the treatment of breast cancer in postmenopausal women… Expand
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Highly Cited
2009
Highly Cited
2009
UDP-Glucuronosyltransferases (UGTs) 2B7 and UGT2B17 Display Converse Specificity in Testosterone and Epitestosterone Glucuronidation, whereas UGT2A1 Conjugates Both Androgens Similarly
Testosterone and epitestosterone are endogenous steroids that differ in the configuration of the hydroxyl-bearing carbon at C-17… Expand
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Review
2008
Review
2008
Inactivation of androgens by UDP-glucuronosyltransferases in the human prostate.
In the human prostate, dihydrotestosterone (DHT) -- the natural androgen having the highest affinity for the androgen receptor… Expand
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Highly Cited
2008
Highly Cited
2008
Deletion polymorphism of the UGT2B17 gene is associated with increased risk for prostate cancer and correlated to gene expression in the prostate
Metabolism of androgens includes glucuronidation, the major pathway of steroid elimination in several steroid target tissues… Expand
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Highly Cited
2007
Highly Cited
2007
The uridine diphosphate glucuronosyltransferase 2B15 D85Y and 2B17 deletion polymorphisms predict the glucuronidation pattern of androgens and fat mass in men.
CONTEXT Previous in vitro studies have demonstrated that the UDP glucuronosyltransferase (UGT)2B15 and UGT2B17 glucuronidate… Expand
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Highly Cited
2001
Highly Cited
2001
Relative enzymatic activity, protein stability, and tissue distribution of human steroid-metabolizing UGT2B subfamily members.
Androgens and estrogens play major roles in cell differentiation, cell growth, and peptide secretion in steroid target tissues… Expand
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Review
1998
Review
1998
Characterization and regulation of UDP-glucuronosyltransferases in steroid target tissues
Conjugation of compounds by glucuronidation is a pathway found in all vertebrates studied to date. Although, it is widely… Expand
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Highly Cited
1996
Highly Cited
1996
Isolation and Characterization of a Novel cDNA Encoding a Human UDP-Glucuronosyltransferase Active on C19 Steroids*
To isolate cDNA clones encoding novel UGT2B enzymes, human prostate and LNCaP cell cDNA libraries were screened using a pool of… Expand
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