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UDP-Glucuronosyltransferase 2B17

Known as: UGT2B17, EC 2.4.1.17, UDP-Glucuronyltransferase, Family 2, Beta-17 
UDP-glucuronosyltransferase 2B17 (530 aa, ~61 kDa) is encoded by the human UGT2B17 gene. This protein plays a role in the metabolism of steroids and… Expand
National Institutes of Health

Papers overview

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2016
2016
Glucuronidation is an enzymatic process that terminally inactivates steroid hormones, including estrogens and androgens, thereby… Expand
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2013
2013
Genetic polymorphisms in combination with the Western‐style diet, physical inactivity, smoking, excessive alcohol consumption… Expand
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Highly Cited
2010
Highly Cited
2010
Objective Exemestane is a third-generation aromatase inhibitor used in the treatment of breast cancer in postmenopausal women… Expand
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Highly Cited
2009
Highly Cited
2009
Testosterone and epitestosterone are endogenous steroids that differ in the configuration of the hydroxyl-bearing carbon at C-17… Expand
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Review
2008
Review
2008
In the human prostate, dihydrotestosterone (DHT) -- the natural androgen having the highest affinity for the androgen receptor… Expand
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Highly Cited
2008
Highly Cited
2008
Metabolism of androgens includes glucuronidation, the major pathway of steroid elimination in several steroid target tissues… Expand
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Highly Cited
2007
Highly Cited
2007
CONTEXT Previous in vitro studies have demonstrated that the UDP glucuronosyltransferase (UGT)2B15 and UGT2B17 glucuronidate… Expand
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Highly Cited
2001
Highly Cited
2001
Androgens and estrogens play major roles in cell differentiation, cell growth, and peptide secretion in steroid target tissues… Expand
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Review
1998
Review
1998
Conjugation of compounds by glucuronidation is a pathway found in all vertebrates studied to date. Although, it is widely… Expand
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Highly Cited
1996
Highly Cited
1996
To isolate cDNA clones encoding novel UGT2B enzymes, human prostate and LNCaP cell cDNA libraries were screened using a pool of… Expand
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