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UDP-Glucuronosyltransferase 2B17

Known as: UGT2B17, EC 2.4.1.17, UDP-Glucuronyltransferase, Family 2, Beta-17 
UDP-glucuronosyltransferase 2B17 (530 aa, ~61 kDa) is encoded by the human UGT2B17 gene. This protein plays a role in the metabolism of steroids and… 
National Institutes of Health

Related topics

Related topics

12 relations
Carbohydrate MetabolismEnzyme GeneGlycosyltransferase GenePentose and Glucuronate Interconversions Pathway

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
Hepatic Abundance and Activity of Androgen- and Drug-Metabolizing Enzyme UGT2B17 Are Associated with Genotype, Age, and Sex
The major objective of this study was to investigate the association of genetic and nongenetic factors with variability in… 
2015
2015
Regulation of Human UGT2B15 and UGT2B17 by miR-376c in Prostate Cancer Cell Lines
Given the prime importance of UDP-glucuronosyltransferase (UGT) 2B15 and UGT2B17 in inactivating testosterone and… 
2013
2013
Androgen glucuronidation: an unexpected target for androgen deprivation therapy, with prognosis and diagnostic implications.
Androgen deprivation therapy (ADTh) remains a mainstay of prostate cancer treatment, but its efficacy is bypassed by mechanisms… 
Highly Cited
2013
Highly Cited
2013
Overexpression of uridine diphospho glucuronosyltransferase 2B17 in high-risk chronic lymphocytic leukemia.
Uridine diphospho glucuronosyltransferase 2B17 (UGT2B17) glucuronidates androgens and xenobiotics including certain drugs. The… 
2013
2013
Variation in Trans-3′-Hydroxycotinine Glucuronidation Does Not Alter the Nicotine Metabolite Ratio or Nicotine Intake
Background CYP2A6 metabolizes nicotine to its primary metabolite cotinine and also mediates the metabolism of cotinine to trans-3… 
Review
2008
Review
2008
Clinical, endocrine, and molecular findings in 17β -hydroxysteroid dehydrogenase type 3 deficiency
The 17β-hydroxysteroid dehydrogenases (17βHSD) gene family comprises different enzymes involved in the biosynthesis of active… 
Highly Cited
2007
Highly Cited
2007
Association between polymorphisms in HSD3B1 and UGT2B17 and prostate cancer risk.
Highly Cited
2007
Highly Cited
2007
The uridine diphosphate glucuronosyltransferase 2B15 D85Y and 2B17 deletion polymorphisms predict the glucuronidation pattern of androgens and fat mass in men.
CONTEXT Previous in vitro studies have demonstrated that the UDP glucuronosyltransferase (UGT)2B15 and UGT2B17 glucuronidate… 
Review
1998
Review
1998
Characterization and regulation of UDP-glucuronosyltransferases in steroid target tissues 1 1 Proceedings of the 13th International Symposium of the Journal of Steroid Biochemistry & Molecular…
Highly Cited
1998
Highly Cited
1998
Effect of interleukins on UGT2B15 and UGT2B17 steroid uridine diphosphate-glucuronosyltransferase expression and activity in the LNCaP cell line.
Cytokines are known to modulate the level of both phase 1 and phase 2 drug-metabolizing enzymes in hepatocytes. Although the… 
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