UDP-Glucuronosyltransferase 2B17

Known as: UGT2B17, EC 2.4.1.17, UDP-Glucuronyltransferase, Family 2, Beta-17 
UDP-glucuronosyltransferase 2B17 (530 aa, ~61 kDa) is encoded by the human UGT2B17 gene. This protein plays a role in the metabolism of steroids and… (More)
National Institutes of Health

Related topics

Related topics

11 relations
Carbohydrate MetabolismEnzyme GeneGlycosyltransferase GenePentose and Glucuronate Interconversions Pathway
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Papers overview

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2013
2013
Overexpression of uridine diphospho glucuronosyltransferase 2B17 in high-risk chronic lymphocytic leukemia.
Uridine diphospho glucuronosyltransferase 2B17 (UGT2B17) glucuronidates androgens and xenobiotics including certain drugs. The… (More)
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2012
2012
Evaluation of UDP-glucuronosyltransferase 2B17 (UGT2B17) and dihydrofolate reductase (DHFR) genes deletion and the expression level of NGX6 mRNA in breast cancer
The present study was aimed to investigate the possible association between 19-base pair (bp) deletion polymorphism of the DHFR… (More)
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2010
2010
Function of UDP-glucuronosyltransferase 2B17 (UGT2B17) is involved in endometrial cancer.
Endometrial cancer (EC) is a steroid hormone-dependent cancer. Uridine 5'-diphospho-glucuronosyltransferase enzymes conjugate and… (More)
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2009
2009
UDP-glucuronosyltransferases (UGTs) 2B7 and UGT2B17 display converse specificity in testosterone and epitestosterone glucuronidation, whereas UGT2A1 conjugates both androgens similarly.
Testosterone and epitestosterone are endogenous steroids that differ in the configuration of the hydroxyl-bearing carbon at C-17… (More)
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Highly Cited
2008
Highly Cited
2008
Expression of UGT1A and UGT2B mRNA in human normal tissues and various cell lines.
UDP-glucuronosyltransferases (UGTs) are major phase II drug metabolism enzymes that catalyze the glucuronidation of numerous… (More)
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Review
2008
Review
2008
Inactivation of androgens by UDP-glucuronosyltransferases in the human prostate.
In the human prostate, dihydrotestosterone (DHT) -- the natural androgen having the highest affinity for the androgen receptor… (More)
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2007
2007
The uridine diphosphate glucuronosyltransferase 2B15 D85Y and 2B17 deletion polymorphisms predict the glucuronidation pattern of androgens and fat mass in men.
CONTEXT Previous in vitro studies have demonstrated that the UDP glucuronosyltransferase (UGT)2B15 and UGT2B17 glucuronidate… (More)
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Highly Cited
2001
Highly Cited
2001
Relative enzymatic activity, protein stability, and tissue distribution of human steroid-metabolizing UGT2B subfamily members.
Androgens and estrogens play major roles in cell differentiation, cell growth, and peptide secretion in steroid target tissues… (More)
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Review
1998
Review
1998
Characterization and regulation of UDP-glucuronosyltransferases in steroid target tissues
Conjugation of compounds by glucuronidation is a pathway found in all vertebrates studied to date. Although, it is widely… (More)
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1997
1997
Differential regulation of two uridine diphospho-glucuronosyltransferases, UGT2B15 and UGT2B17, in human prostate LNCaP cells.
Although androgens are important regulators in the prostate, other effectors such as growth factors may also act to maintain… (More)
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