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Studies on the metabolism of the α-pyrrolidinophenone designer drug methylenedioxy-pyrovalerone (MDPV) in rat and human urine and human liver microsomes using GC-MS and LC-high-resolution MS and its
TLDR
The aim of the presented work was to identify the phase I and II metabolites of MDPV and the human cytochrome-P450 (CYP) isoenzymes responsible for its main metabolic step(s), and the detectability of M DPV in urine by the authors' systematic toxicological analysis (STA).
Beta-keto amphetamines: studies on the metabolism of the designer drug mephedrone and toxicological detection of mephedrone, butylone, and methylone in urine using gas chromatography–mass spectrometry
TLDR
The STA procedure allowed the detection of mephedrone, butylone, methylone, and their metabolites in urine of rats treated with doses corresponding to those reported for abuse of amphetamines and should be suitable for proof of an intake of the bk-designer drugs in human urine.
The Role of Human Hepatic Cytochrome P450 Isozymes in the Metabolism of Racemic 3,4-Methylenedioxy-Methamphetamine and Its Enantiomers
TLDR
The different pharmacokinetic properties of the MDMA enantiomers may be caused by enantioselective metabolism by CYP2C19 and CYD2D6.
Metabolism of designer drugs of abuse: an updated review.
TLDR
The metabolism of new designer drugs of abuse that have emerged on the black market during the last years and the cytochrome P450 or monoamineoxidase isoenzyme-dependent metabolism are reviewed.
Automated mass spectral deconvolution and identification system for GC-MS screening for drugs, poisons, and metabolites in urine.
TLDR
AMDIS proved to be a reliable and powerful tool for daily routine and emergency toxicology but can identify only targets present in the user-defined target library and may therefore not indicate unknown compounds that might be relevant in clinical and forensic toxicology.
Development of the first metabolite-based LC-MSn urine drug screening procedure-exemplified for antidepressants
TLDR
The presentedLC-MSn method complements established GC-MS or LC-MS procedures in the authors’ lab and allowed detecting unknown compounds based on known fragment structures and confirms the body passage.
Benzofuran analogues of amphetamine and methamphetamine: studies on the metabolism and toxicological analysis of 5-APB and 5-MAPB in urine and plasma using GC-MS and LC-(HR)-MSn techniques
Abstract5-APB (5-(2-aminopropyl)benzofuran) and its N-methyl derivative 5-MAPB (N-methyl-5-(2-aminopropyl)benzofuran) are analogues of amphetamine and methamphetamine, respectively, and belong to the
New designer drug alpha-pyrrolidinovalerophenone (PVP): studies on its metabolism and toxicological detection in rat urine using gas chromatographic/mass spectrometric techniques.
TLDR
Nine different human cytochrome P450 isoenzymes in the side chain hydroxylation of PVP was investigated and CYP 2B6, 2C19, 2D6, and 3A4 were found to catalyze this reaction.
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