UCS 1025A

UCS1025A is a fungal polyketide/alkaloid that displays strong inhibition of telomerase. The structures of UCS1025A and related… (More)

As part of our screening program to find new antitrypanosomal compounds, we evaluate isolates from soil-dwelling microorganisms… (More)

There is an urgent need of novel approaches to drugs in the cancer, HIV, and bacterial areas. Increasing resistance to… (More)

The current scope and limitations of organocatalytic reactions and the consequences for the strategic planning of natural product… (More)

Telomerase has been proposed as a selective target for cancer chemotherapy. We established a forward chemical genetics approach… (More)

The enantioselective total synthesis of the telomerase inhibitor UCS1025A has been accomplished. The key transformation involves… (More)

A synthesis of the structurally fascinating fungal metabolite UCS1025A (1) was accomplished. It features a likely biomimetic… (More)

Modified Moffat oxidation of alcohols 17, 22, and 25 afforded aldehydes that underwent intramolecular aldol reactions on… (More)

[structure: see text] UCS1025A and B, novel pentacyclic polyketides with an unprecedented furopyrrolizidine skeleton, were… (More)

antimicrobial activity, and antiproliferative activity against humantumor cell lines. In this paper, we describe the taxonomy of… (More)