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UACC-257

A melanoma cell line established from a patient with cutaneous melanoma.
National Institutes of Health

Papers overview

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2018
2018
Design, synthesis and evaluation of novel sulfonamides as potential anticancer agents
Based on modern literature data about biological activity of E7010 derivatives, a series of new sulfonamides as potential… Expand
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2017
2017
NADPH oxidase 5 (NOX5)—induced reactive oxygen signaling modulates normoxic HIF‐1α and p27Kip1 expression in malignant melanoma and other human tumors
NADPH oxidase 5 (NOX5) generated reactive oxygen species (ROS) have been implicated in signaling cascades that regulate cancer… Expand
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2015
2015
Pennogenyl saponins induce cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells.
ETHNOPHARMACOLOGICAL RELEVANCE Pennogenyl saponins, the characterized components of Rhizoma Paridis, have been reported to have… Expand
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2013
2013
Characterization of NADPH oxidase 5 expression in human tumors and tumor cell lines with a novel mouse monoclonal antibody.
Reactive oxygen species generated by NADPH oxidase 5 (Nox5) have been implicated in physiological and pathophysiological… Expand
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2008
2008
Plitidepsin has a dual effect inhibiting cell cycle and inducing apoptosis via Rac1/c-Jun NH2-terminal kinase activation in human melanoma cells.
Melanoma is the most aggressive skin cancer and a serious health problem worldwide because of its increasing incidence and the… Expand
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2007
2007
Chemical composition and cytotoxic activity of the leaf essential oil of Eugenia zuchowskiae from Monteverde, Costa Rica
The leaf essential oil of Eugenia zuchowskiae from Monteverde, Costa Rica, has been obtained by hydrodistillation and analyzed by… Expand
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Highly Cited
2006
Highly Cited
2006
CR011, a fully human monoclonal antibody-auristatin E conjugate, for the treatment of melanoma.
PURPOSE Advanced melanoma is a highly drug-refractory neoplasm representing a significant unmet medical need. We sought to… Expand
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2004
2004
Induction of growth inhibition and G1 arrest in human cancer cell lines by relatively low-toxic diamantane derivatives.
We describe the discovery of a novel series of antitumor diamantane derivatives which induces G1 arrest in Colo 205 cells. Eight… Expand
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2004
2004
A novel class of achiral seco-analogs of CC-1065 and the duocarmycins: design, synthesis, DNA binding, and anticancer properties.
The synthesis, DNA binding properties, and in vitro and in vivo anticancer activity of fifteen achiral seco-cyclopropylindoline… Expand
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2001
2001
Development of C-20 modified betulinic acid derivatives as antitumor agents.
Chemical modifications were performed on C-20 position of betulinic acid for a structure-activity relationship study. The… Expand
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