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U4/U6 x U5 tri-snRNP complex

Known as: U4/U6 x U5 tri-snRNP complex location, U4/U6.U5 snRNP complex, U4/U6.U5 snRNP complex location 
A ribonucleoprotein complex formed by the association of the U4/U6 and U5 small nuclear ribonucleoproteins. [GOC:krc, GOC:pr, PMID:11867543]
National Institutes of Health

Related topics

Related topics

3 relations

Broader (1)

U2-type precatalytic spliceosome

Narrower (2)

U4/U6 snRNPU5 snRNP location

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2013
Highly Cited
2013
A Pre-mRNA-Splicing Factor Is Required for RNA-Directed DNA Methylation in Arabidopsis
Cytosine DNA methylation is a stable epigenetic mark that is frequently associated with the silencing of genes and transposable… 
2004
2004
Human U4/U6 snRNP Recycling Factor p110: Mutational Analysis Reveals the Function of the Tetratricopeptide Repeat Domain in Recycling
ABSTRACT After each spliceosome cycle, the U4 and U6 snRNAs are released separately and are recycled to the functional U4/U6… 
2002
2002
Direct probing of RNA structure and RNA-protein interactions in purified HeLa cell's and yeast spliceosomal U4/U6.U5 tri-snRNP particles.
The U4/U6.U5 tri-snRNP is a key component of spliceosomes. By using chemical reagents and RNases, we performed the first… 
Highly Cited
1999
Highly Cited
1999
A Novel Genetic Screen for snRNP Assembly Factors in Yeast Identifies a Conserved Protein, Sad1p, Also Required for Pre-mRNA Splicing
ABSTRACT The assembly pathway of spliceosomal snRNPs in yeast is poorly understood. We devised a screen to identify mutations… 
Highly Cited
1997
Highly Cited
1997
The human U4/U6 snRNP contains 60 and 90kD proteins that are structurally homologous to the yeast splicing factors Prp4p and Prp3p.
Immunoaffinity-purified human 25S [U4/U6.U5] tri-snRNPs harbor a set of polypeptides, termed the tri-snRNP proteins, that are not… 
1997
1997
The yeast Prp3 protein is a U4/U6 snRNP protein necessary for integrity of the U4/U6 snRNP and the U4/U6.U5 tri-snRNP.
Previously, yeast prp3 mutants were found to be blocked prior to the first catalytic step of pre-mRNA splicing. No splicing… 
Highly Cited
1994
Highly Cited
1994
A stem/loop in U6 RNA defines a conformational switch required for pre-mRNA splicing.
U6 small nuclear RNA (snRNA) is an essential component of the spliceosome, the ribonucleoprotein complex that carries out the… 
Highly Cited
1991
Highly Cited
1991
Analysis of small nuclear ribonucleoproteins (RNPs) in Trypanosoma brucei: structural organization and protein components of the spliced leader RNP
trans splicing in Trypanosoma brucei involves the ligation of the 40-nucleotide spliced leader (SL) to each of the exons of large… 
Highly Cited
1990
Highly Cited
1990
Domains of yeast U4 spliceosomal RNA required for PRP4 protein binding, snRNP-snRNP interactions, and pre-mRNA splicing in vivo.
U4 small nuclear RNA (snRNA) contains two intramolecular stem-loop structures, located near each end of the molecule. The 5' stem… 
Highly Cited
1986
Highly Cited
1986
Pre-mRNA splicing in vitro requires intact U4/U6 small nuclear ribonucleoprotein
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