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U 78517F

Known as: U-78517F, U78517F 
National Institutes of Health

Related topics

Related topics

9 relations
2-methyl aminochromanU 78517GU 83836E

Broader (5)

Anti-Asthmatic AgentsAntioxidantsChromansNeuroprotective Agents

Narrower (1)

PNU 83836E

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
1996
Highly Cited
1996
Neuroprotective effects of hypothermia and U‐78517F in cerebral ischemia are due to reducing oxygen‐based free radicals: An electron paramagnetic resonance study with gerbils
Free radicals are implicated as causative agents in various forms of tissue destruction. Considerable circumstantial evidence… 
Highly Cited
1996
Highly Cited
1996
Diisopropylphosphorofluoridate-induced muscle hyperactivity associated with enhanced lipid peroxidation in vivo.
1996
1996
An application of electron paramagnetic resonance to evaluate nitric oxide and its quenchers.
Electron paramagnetic resonance (EPR) spectrometry has been used for detection of free radicals, including nitric oxide (NO). The… 
1995
1995
21-aminosteroid and 2-(aminomethyl)chromans inhibition of arachidonic acid-induced lipid peroxidation and permeability enhancement in bovine brain microvessel endothelial cell monolayers.
Highly Cited
1994
Highly Cited
1994
SB 211475, a metabolite of carvedilol, a novel antihypertensive agent, is a potent antioxidant.
1994
1994
Superoxide dismutase, catalase, and U78517F attenuate neuronal damage in gerbils with repeated brief ischemic insults
Repeated ischemic insults at one hour intervals result in more severe neuronal damage than a single similar duration insult. The… 
Highly Cited
1993
Highly Cited
1993
Kainic acid-induced lipid peroxidation: protection with butylated hydroxytoluene and U78517F in primary cultures of cerebellar granule cells
Highly Cited
1991
Highly Cited
1991
U-78517F: a potent inhibitor of lipid peroxidation with activity in experimental brain injury and ischemia.
U-78517F (2-[4-[2,6-di-(1-pyrrolidinyl)-4-pyridinyl)-1-piperazinyl] methyl]-3,4-dihydro-2,5,7,8-tetramethyl-2H-1-benzopyran-6-ol… 
Highly Cited
1991
Highly Cited
1991
Effect of oxygen-free radical scavengers on survival in sepsis.
UNLABELLED Sepsis remains a leading cause of death in the surgical intensive care unit (SICU) patient following major surgery or… 
1990
1990
Nonsteroidal lazaroid U78517F in models of focal and global ischemia.
U78517F is a novel inhibitor of iron-catalyzed lipid peroxidation that combines the tetramethylchroman antioxidant ring portion… 
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