Tyrosine Kinase Domain

A protein domain that binds a protein and catalyzes the covalent addition of a phosphate group specifically to a tyrosine residue.
National Institutes of Health

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Highly Cited
2006
Highly Cited
2006
The RET proto-oncogene encodes a receptor tyrosine kinase for the glial cell line-derived neurotrophic factor family of ligands… (More)
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Highly Cited
2004
Highly Cited
2004
BACKGROUND Most patients with non-small-cell lung cancer have no response to the tyrosine kinase inhibitor gefitinib, which… (More)
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Review
2004
Review
2004
Src and Src-family protein kinases are proto-oncogenes that play key roles in cell morphology, motility, proliferation, and… (More)
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Highly Cited
1999
Highly Cited
1999
The Janus family of protein tyrosine kinases (JAKs) regulate cellular processes involved in cell growth, differentiation and… (More)
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Highly Cited
1998
Highly Cited
1998
Receptor tyrosine kinases Flt-1 and Flk-1/KDR, and their ligand, the vascular endothelial growth factor (VEGF), were shown to be… (More)
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Highly Cited
1998
Highly Cited
1998
Angiogenesis, the sprouting of new blood vessels from pre-existing ones, is an essential physiological process in development… (More)
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Highly Cited
1997
Highly Cited
1997
A new class of protein tyrosine kinase inhibitors was identified that is based on an oxindole core (indolinones). Two compounds… (More)
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Highly Cited
1996
Highly Cited
1996
The crystal structure of the tyrosine kinase domain of fibroblast growth factor receptor 1 (FGFR1K) has been determined in its… (More)
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Highly Cited
1994
Highly Cited
1994
HIRSCHSPRUNG'S disease is a genetic disorder of neural crest development affecting 1 in 5,000 births. It is characterized by the… (More)
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Highly Cited
1990
Highly Cited
1990
A new human gene encoding a receptor-type tyrosine kinase was isolated by a weak cross-hybridization with v-ros oncogene. A cDNA… (More)
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