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Tyrosine Kinase Domain
A protein domain that binds a protein and catalyzes the covalent addition of a phosphate group specifically to a tyrosine residue.
National Institutes of Health
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Related topics
Related topics
50 relations
BTK protein, human
CSK protein, human
Discoidin Domain-Containing Receptor 2, Human
EPHA3 protein, human
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2009
Highly Cited
2009
The juxtamembrane region of the EGF receptor functions as an activation domain.
M. Red Brewer
,
Sung-Hee Choi
,
+4 authors
G. Carpenter
Molecules and Cells
2009
Corpus ID: 3580987
Highly Cited
2007
Highly Cited
2007
FLT3 tyrosine kinase domain mutations are biologically distinct from and have a significantly more favorable prognosis than FLT3 internal tandem duplications in patients with acute myeloid leukemia.
A. Mead
,
D. Linch
,
R. Hills
,
K. Wheatley
,
A. Burnett
,
R. Gale
Blood
2007
Corpus ID: 28207956
The prognostic impact of tyrosine kinase domain (TKD) mutations of the fms-like tyrosine kinase-3 (FLT3) gene in acute myeloid…
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Highly Cited
2006
Highly Cited
2006
Clinical resistance to the kinase inhibitor PKC412 in acute myeloid leukemia by mutation of Asn-676 in the FLT3 tyrosine kinase domain.
F. Heidel
,
F. Solem
,
+17 authors
T. Fischer
Blood
2006
Corpus ID: 17769414
Activating mutations in the FLT3 tyrosine kinase (TK) occur in approximately 35% of patients with acute myeloid leukemia (AML…
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Highly Cited
2005
Highly Cited
2005
Mutation in the Tyrosine Kinase Domain of Epidermal Growth Factor Receptor Is a Predictive and Prognostic Factor for Gefitinib Treatment in Patients with Non–Small Cell Lung Cancer
T. Chou
,
C. Chiu
,
+7 authors
C. Tsai
Clinical Cancer Research
2005
Corpus ID: 36764588
Purpose: Mutations in epidermal growth factor receptor (EGFR) can be used to predict the tumor response of patients receiving…
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Highly Cited
2005
Highly Cited
2005
EGFR tyrosine kinase domain mutations are detected in histologically normal respiratory epithelium in lung cancer patients.
Ximing Tang
,
H. Shigematsu
,
+5 authors
I. Wistuba
Cancer Research
2005
Corpus ID: 25187797
To determine whether EGFR tyrosine kinase domain mutations are early events in the pathogenesis of lung adenocarcinomas, we…
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Highly Cited
2000
Highly Cited
2000
Regulation of the Jak2 Tyrosine Kinase by Its Pseudokinase Domain
P. Saharinen
,
K. Takaluoma
,
O. Silvennoinen
Molecular and Cellular Biology
2000
Corpus ID: 6760645
ABSTRACT Activation of Jak tyrosine kinases through hematopoietic cytokine receptors occurs as a consequence of ligand-induced…
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Highly Cited
1995
Highly Cited
1995
A recurrent mutation in the tyrosine kinase domain of fibroblast growth factor receptor 3 causes hypochondroplasia
G. Bellus
,
I. Mcintosh
,
+8 authors
C. Francomano
Nature Genetics
1995
Corpus ID: 22560890
Hypochondroplasia (MIM 146000) is an autosomal dominant skeletal dysplasia with skeletal features similar to but milder than…
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Highly Cited
1993
Highly Cited
1993
Alternative forms of rat TrkC with different functional capabilities
D. Valenzuela
,
P. Maisonpierre
,
+7 authors
G. Yancopoulos
Neuron
1993
Corpus ID: 23139106
Highly Cited
1991
Highly Cited
1991
Cloning of a complementary DNA for a protein-tyrosine kinase that specifically phosphorylates a negative regulatory site of p60c-src
S. Nada
,
M. Okada
,
A. Macauley
,
Jonathan A. Cooper
,
H. Nakagawa
Nature
1991
Corpus ID: 4363527
THE protein-tyrosine kinase activity of the proto-oncogene product p60c-src is negatively regulated by the phosphorylation of a…
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Highly Cited
1991
Highly Cited
1991
Molecular cloning of a porcine gene syk that encodes a 72-kDa protein-tyrosine kinase showing high susceptibility to proteolysis.
Takanobu Taniguchi
,
Takashi Kobayashi
,
+7 authors
Hirohei Yamamura
Journal of Biological Chemistry
1991
Corpus ID: 24945806
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