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Tryptase Beta-2, human

Known as: Tryptase Beta-2, Tryptase Beta III, Tryptase II 
Tryptase beta-2 (275 aa, ~31 kDa) is encoded by the human TPSB2 gene. This protein is involved in protein degradation.
National Institutes of Health

Related topics

Related topics

12 relations
ChymaseEnzyme GeneExtracellular SpaceHydrolysis

Broader (1)

TRYPTASE

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2003
2003
Role for chymase in heart failure: angiotensin II-dependent or -independent mechanisms?
One of the major questions regarding the role of angiotensin II (Ang II) in the pathophysiology of heart failure has been whether… 
Highly Cited
2003
Highly Cited
2003
Albumin Is a Substrate of Human Chymase
Human chymase is a chymotryptic serine peptidase stored and secreted by mast cells. Compared with other chymotryptic enzymes… 
Highly Cited
2002
Highly Cited
2002
Mast Cell Chymase Degrades ApoE and ApoA-II in ApoA-I–Knockout Mouse Plasma and Reduces Its Ability to Promote Cellular Cholesterol Efflux
Objective—Mast cell chymase is a chymotryptic heparin proteoglycan–bound neutral protease that exerts its activity in… 
Highly Cited
2001
Highly Cited
2001
Mast cell chymase expression and mast cell phenotypes in human rejected kidneys.
BACKGROUND Mast cells (MCs) are known to participate in various types of chronic disease, but their role in chronic renal… 
Highly Cited
1999
Highly Cited
1999
Generation of Catalytically Active Granzyme K fromEscherichia coli Inclusion Bodies and Identification of Efficient Granzyme K Inhibitors in Human Plasma*
Granzymes are granule-stored lymphocyte serine proteases that are implicated in T- and natural killer cell-mediated cytotoxic… 
1998
1998
Human Chymase, an Enzyme Forming Novel Bioactive 31-Amino Acid Length Endothelins
We report the novel role of human chymase in the production of bioactive 31-amino acid length endothelins (ETs), which may play a… 
Highly Cited
1996
Highly Cited
1996
Chymase in exocytosed rat mast cell granules effectively proteolyzes apolipoprotein AI-containing lipoproteins, so reducing the cholesterol efflux-inducing ability of serum and aortic intimal fluid.
Degranulated mast cells are present in human fatty streaks. Chymase in granules released from degranulated rat serosal mast cells… 
Highly Cited
1996
Highly Cited
1996
Mast cells expressing chymase but not tryptase can be derived by culturing human progenitors in conditioned medium obtained from a human mastocytosis cell strain with c-kit ligand.
Human mast cells (MC) were derived from umbilical cord blood and bone marrow progenitors cultured in the presence of a… 
Review
1995
Review
1995
The chymase-angiotensin system in humans: biochemistry, molecular biology and potential role in cardiovascular diseases.
Angiotensin I-converting enzyme (ACE) inhibitors are highly effective in the treatment of cardiovascular diseases. However, the… 
Highly Cited
1989
Highly Cited
1989
Reaction of human skin chymotrypsin-like proteinase chymase with plasma proteinase inhibitors.
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