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Tropomodulin
Known as:
Tropomodulin [Chemical/Ingredient]
An actin capping protein that binds to the pointed-end of ACTIN. It functions in the presence of TROPOMYOSIN to inhibit microfilament elongation.
National Institutes of Health
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In Blood
Process of secretion
TMOD1 gene
agonists
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TMOD1 protein, human
Tmod1 protein, rat
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2006
2006
Tropomodulin 3 Binds to Actin Monomers*
R. Fischer
,
E. Yarmola
,
+4 authors
V. Fowler
Journal of Biological Chemistry
2006
Corpus ID: 46678475
Regulation of the actin cytoskeleton by filament capping proteins is critical to myriad dynamic cellular functions. The ability…
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Highly Cited
2005
Highly Cited
2005
Structural requirements of tropomodulin for tropomyosin binding and actin filament capping.
A. Kostyukova
,
Brian A Rapp
,
Andy Choy
,
N. Greenfield
,
S. Hitchcock-DeGregori
Biochemistry
2005
Corpus ID: 22525734
Regulation of actin filament dynamics underlies many cellular functions. Tropomodulin together with tropomyosin can cap the…
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2000
2000
Tropomodulin and tropomyosin mediate lens cell actin cytoskeleton reorganization in vitro.
R. Fischer
,
A. Lee
,
V. Fowler
Investigative ophthalmology & visual science
2000
Corpus ID: 16348192
PURPOSE To determine the role of the actin cytoskeleton regulatory proteins tropomyosin and tropomodulin (Tmod) in the…
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Highly Cited
1999
Highly Cited
1999
Identification of a Novel Tropomodulin Isoform, Skeletal Tropomodulin, That Caps Actin Filament Pointed Ends in Fast Skeletal Muscle*
A. Almenar-Queralt
,
Andria Lee
,
C. Conley
,
L. R. de Pouplana
,
V. Fowler
The Journal of Biological Chemistry
1999
Corpus ID: 29191849
Tropomodulin (E-Tmod) is an actin filament pointed end capping protein that maintains the length of the sarcomeric actin…
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Highly Cited
1998
Highly Cited
1998
Myofibril degeneration caused by tropomodulin overexpression leads to dilated cardiomyopathy in juvenile mice.
Mark A Sussman
,
S. Welch
,
+5 authors
T. Kimball
The Journal of clinical investigation
1998
Corpus ID: 12474871
Loss of myofibril organization is a common feature of chronic dilated and progressive cardiomyopathy. To study how the heart…
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Highly Cited
1998
Highly Cited
1998
Altered expression of tropomodulin in cardiomyocytes disrupts the sarcomeric structure of myofibrils.
Mark A Sussman
,
S. Baqué
,
+5 authors
L. Kedes
Circulation research
1998
Corpus ID: 8245717
Tropomodulin is a tropomyosin-binding protein that terminates "pointed-end" actin filament polymerization. To test the hypothesis…
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Highly Cited
1995
Highly Cited
1995
Requirement of pointed-end capping by tropomodulin to maintain actin filament length in embryonic chick cardiac myocytes
C. Gregorio
,
A. Weber
,
M. Bondad
,
C. Pennise
,
V. Fowler
Nature
1995
Corpus ID: 4279512
CONTROL of actin filament length and dynamics is important for cell motility and architecture and is regulated in part by capping…
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Highly Cited
1995
Highly Cited
1995
Mechanisms of thin filament assembly in embryonic chick cardiac myocytes: tropomodulin requires tropomyosin for assembly
C. Gregorio
,
V. Fowler
The Journal of cell biology
1995
Corpus ID: 15867900
Tropomodulin is a pointed end capping protein for tropomyosin-coated actin filaments that is hypothesized to play a role in…
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Highly Cited
1994
Highly Cited
1994
Tropomodulin caps the pointed ends of actin filaments
A. Weber
,
C. Pennise
,
G. Babcock
,
V. Fowler
The Journal of cell biology
1994
Corpus ID: 21008588
Many proteins have been shown to cap the fast growing (barbed) ends of actin filaments, but none have been shown to block…
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Highly Cited
1990
Highly Cited
1990
Tropomodulin: a cytoskeletal protein that binds to the end of erythrocyte tropomyosin and inhibits tropomyosin binding to actin
V. Fowler
The Journal of cell biology
1990
Corpus ID: 1044840
Human erythrocytes contain a Mr 43,000 tropomyosin-binding protein that is unrelated to actin and that has been proposed to play…
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