Tropomodulin

Regulation of actin filament dynamics underlies many cellular functions. Tropomodulin together with tropomyosin can cap the… Expand

PURPOSE To determine the role of the actin cytoskeleton regulatory proteins tropomyosin and tropomodulin (Tmod) in the… Expand

The pointed end capping protein, tropomodulin, increases the critical concentration of barbed end capped actin,i.e. it lowers the… Expand

Loss of myofibril organization is a common feature of chronic dilated and progressive cardiomyopathy. To study how the heart… Expand

Tropomodulin is a tropomyosin-binding protein that terminates "pointed-end" actin filament polymerization. To test the hypothesis… Expand

CONTROL of actin filament length and dynamics is important for cell motility and architecture and is regulated in part by capping… Expand

Tropomodulin is a pointed end capping protein for tropomyosin-coated actin filaments that is hypothesized to play a role in… Expand

Many proteins have been shown to cap the fast growing (barbed) ends of actin filaments, but none have been shown to block… Expand

Tropomodulin is a 40.6-kDa protein that binds to one end of the rod-like tropomyosin and inhibits its cooperativity and binding… Expand

Human erythrocytes contain a Mr 43,000 tropomyosin-binding protein that is unrelated to actin and that has been proposed to play… Expand