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Tropomodulin

Known as: Tropomodulin [Chemical/Ingredient] 
An actin capping protein that binds to the pointed-end of ACTIN. It functions in the presence of TROPOMYOSIN to inhibit microfilament elongation.
National Institutes of Health

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In BloodProcess of secretionTMOD1 geneagonists
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TMOD1 protein, humanTmod1 protein, rat

Papers overview

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2006
2006
Tropomodulin 3 Binds to Actin Monomers*
Regulation of the actin cytoskeleton by filament capping proteins is critical to myriad dynamic cellular functions. The ability… 
Highly Cited
2005
Highly Cited
2005
Structural requirements of tropomodulin for tropomyosin binding and actin filament capping.
Regulation of actin filament dynamics underlies many cellular functions. Tropomodulin together with tropomyosin can cap the… 
2000
2000
Tropomodulin and tropomyosin mediate lens cell actin cytoskeleton reorganization in vitro.
PURPOSE To determine the role of the actin cytoskeleton regulatory proteins tropomyosin and tropomodulin (Tmod) in the… 
Highly Cited
1999
Highly Cited
1999
Identification of a Novel Tropomodulin Isoform, Skeletal Tropomodulin, That Caps Actin Filament Pointed Ends in Fast Skeletal Muscle*
Tropomodulin (E-Tmod) is an actin filament pointed end capping protein that maintains the length of the sarcomeric actin… 
Highly Cited
1998
Highly Cited
1998
Myofibril degeneration caused by tropomodulin overexpression leads to dilated cardiomyopathy in juvenile mice.
Loss of myofibril organization is a common feature of chronic dilated and progressive cardiomyopathy. To study how the heart… 
Highly Cited
1998
Highly Cited
1998
Altered expression of tropomodulin in cardiomyocytes disrupts the sarcomeric structure of myofibrils.
Tropomodulin is a tropomyosin-binding protein that terminates "pointed-end" actin filament polymerization. To test the hypothesis… 
Highly Cited
1995
Highly Cited
1995
Requirement of pointed-end capping by tropomodulin to maintain actin filament length in embryonic chick cardiac myocytes
CONTROL of actin filament length and dynamics is important for cell motility and architecture and is regulated in part by capping… 
Highly Cited
1995
Highly Cited
1995
Mechanisms of thin filament assembly in embryonic chick cardiac myocytes: tropomodulin requires tropomyosin for assembly
Tropomodulin is a pointed end capping protein for tropomyosin-coated actin filaments that is hypothesized to play a role in… 
Highly Cited
1994
Highly Cited
1994
Tropomodulin caps the pointed ends of actin filaments
Many proteins have been shown to cap the fast growing (barbed) ends of actin filaments, but none have been shown to block… 
Highly Cited
1990
Highly Cited
1990
Tropomodulin: a cytoskeletal protein that binds to the end of erythrocyte tropomyosin and inhibits tropomyosin binding to actin
  • V. Fowler
  • The Journal of cell biology
  • 1990
  • Corpus ID: 1044840
Human erythrocytes contain a Mr 43,000 tropomyosin-binding protein that is unrelated to actin and that has been proposed to play… 
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