Trenimon

 
National Institutes of Health

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Triaziquone

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1992
1992
Modulation of trenimon-induced cytotoxicity by DT-diaphorase in isolated rat hepatocytes under aerobic versus hypoxic conditions.
Trenimon belongs to a class of aziridinylbenzoquinone anticancer drugs that cross the blood-brain barrier. In this study we have… (More)
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1991
1991
The SNQ3 gene of Saccharomyces cerevisiae confers hyper-resistance to several functionally unrelated chemicals
A multi-copy plasmid containing the SNQ3 gene confers hyper-resistance to 4-nitroquinoline-N-oxide (4NQO), Trenimon, MNNG… (More)
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1987
1987
Effect of heat treatment on chromosomal aberrations induced by the alkylating agent trenimon or the restriction endonuclease Alu I in Chinese hamster ovary (CHO) cells.
Heat treatment of CHO cells in the G1-phase of the cell cycle leads to chromatid-type aberrations in first posttreatment… (More)
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Highly Cited
1984
Highly Cited
1984
Somatic mutation and recombination test in Drosophila melanogaster.
A novel test system for the detection of mutagenic and recombinogenic activity of chemicals is described in detail. Drosophila… (More)
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1982
1982
Inhibition of a mouse hepatoma by the alkylating agent trenimon linked to immunoglobulins
Trenimon was conjugated in active alkylating form to rabbit anti-mouse H6 hepatoma globulin (AHG) with retention of antibody… (More)
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1978
1978
The anticlastogenic effect of various combinations of cysteamine, AET, HCT, and amino acids on chromosome damage by Trenimon and bleomycin in human lymphocytes in vitro
The protective activity of the combined application of anticlastogens against the chromosome-damaging action of Trenimon and… (More)
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1975
1975
The rate of sister chromatid exchanges parallel to spontaneous chromosome breakage in Fanconi's anemia and to trenimon-induced aberrations in human lymphocytes and fibroblasts
The incidence of structural chromosome aberrations and the rate of sister chromatid exchanges (SCE) was investigated in… (More)
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Highly Cited
1974
Highly Cited
1974
The internal order of the interphase nucleus
This paper has two parts. The first one is theoretical, whereas in the second, some experimenteal results are reported. Part 1… (More)
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1971
1971
Chemical mutagenesis the Chinese hamster bone marrow as an in vivo test system
1. Endoxan and Trenimon, the alkylating agents tested, are potent cytostatic drugs, therapeutically acting through their… (More)
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1970
1970
Chemische Mutagenese beim Säuger. Das Knochenmark des Chinesischen Hamsters als in vivo-Testsystem. Hämatologische Befunde nach Behandlung mit Trenimon
Exploring systems for chemical mutagenicity testing in mammals it was investigated how far scoring of simple bone marrow smears… (More)
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