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Trefoil Motif

Known as: TFF Domain, P-Type Domain, Trefoil Domain 
Domain found in various secretory polypeptides that has highly conserved cysteine residues that are disulfide bonded in such a way as to generate a… 
National Institutes of Health

Related topics

Related topics

4 relations
TFF1 protein, humanTFF2 protein, humanTFF3 protein, humanTrefoil Family

Papers overview

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Highly Cited
2004
Highly Cited
2004
Immunoassays of human trefoil factors 1 and 2: measured on serum from patients with inflammatory bowel disease
Background: The trefoil factors (TFF1–3) are cysteine‐rich peptides expressed in the gastrointestinal tract where they play a… 
2002
2002
pH and urea dependence of amide hydrogen-deuterium exchange rates in the beta-trefoil protein hisactophilin.
Amide hydrogen/deuterium exchange rates were measured as a function of pH and urea for 37 slowly exchanging amides in the beta… 
Highly Cited
2001
Highly Cited
2001
Effect of Ectopic Expression of Rat Trefoil Factor Family 3 (Intestinal Trefoil Factor) in the Jejunum of Transgenic Mice*
To further examine the function of the trefoil factor family (TFF), the expression of which is up-regulated at sites of injury… 
2001
2001
Trefoil peptides promote restitution of wounded corneal epithelial cells.
The ocular surface shares many characteristics with mucosal surfaces. In both, healing is regulated by peptide growth factors… 
Highly Cited
2000
Highly Cited
2000
Isolation and characterization of putative trefoil peptide receptors
2000
2000
Structure‐based sequence alignment for the β‐trefoil subdomain of the clostridial neurotoxin family provides residue level information about the putative ganglioside binding site
Highly Cited
1998
Highly Cited
1998
Intestinal trefoil factor induces inactivation of extracellular signal-regulated protein kinase in intestinal epithelial cells.
Intestinal trefoil factor (ITF), a small, compact protease-resistant peptide, is abundantly expressed in goblet cells of large… 
Highly Cited
1998
Highly Cited
1998
Short-chain fatty acids inhibit intestinal trefoil factor gene expression in colon cancer cells.
Intestinal trefoil factor (ITF) gene expression was detected in five colon cancer cell lines. ITF was synthesized by mucous cells… 
1998
1998
5'-flanking motifs control cell-specific expression of trefoil factor genes (TFF).
A group of secreted peptides (trefoil factor family; TFF) is abundantly expressed at mucosal surfaces of the gastrointestinal… 
Highly Cited
1994
Highly Cited
1994
Solution structure of a trefoil-motif-containing cell growth factor, porcine spasmolytic protein.
The porcine spasmolytic protein (pSP) is a 106-residue cell growth factor that typifies a family of eukaryotic proteins that… 
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