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Transforming Acidic Coiled-Coil Containing Protein 3

Known as: ERIC1, TACC3, Transforming Acidic Coiled-Coil-Containing Protein 3 
Transforming acidic coiled-coil-containing protein 3 (838 aa, ~90 kDa) is encoded by the human TACC3 gene. This protein may play a role in… Expand
National Institutes of Health

Related topics

Related topics

6 relations
Cell Cycle ControlGenes, RegulatorGenes, cdcTACC3 gene
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Papers overview

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Highly Cited
2010
Highly Cited
2010
Clathrin heavy chain mediates TACC3 targeting to mitotic spindles to ensure spindle stability
CHC binds specifically to aurora A–phosphorylated TACC3, recruiting it to the spindle during mitosis. 
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Highly Cited
2010
Highly Cited
2010
Integrated genomic analyses identify ERRFI1 and TACC3 as glioblastoma-targeted genes
The glioblastoma genome displays remarkable chromosomal aberrations, which harbor critical glioblastoma-specific genes… Expand
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2010
2010
TACC3-TSC2 maintains nuclear envelope structure and controls cell division
Studies of the role of tuberous sclerosis complex (TSC) proteins (TSC1/TSC2) in pathology have focused mainly on their capacity… Expand
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Highly Cited
2008
Highly Cited
2008
Meiotic Regulation of TPX2 Protein Levels Governs Cell Cycle Progression in Mouse Oocytes
Formation of female gametes requires acentriolar spindle assembly during meiosis. Mitotic spindles organize from centrosomes and… Expand
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Highly Cited
2007
Highly Cited
2007
Localization of human TACC3 to mitotic spindles is mediated by phosphorylation on Ser558 by Aurora A: a novel pharmacodynamic method for measuring Aurora A activity.
Aurora A is a serine/threonine protein kinase essential for normal mitotic progression. Aberrant increased expression of Aurora A… Expand
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Highly Cited
2006
Highly Cited
2006
NDEL1 Phosphorylation by Aurora-A Kinase Is Essential for Centrosomal Maturation, Separation, and TACC3 Recruitment
ABSTRACT NDEL1 is a binding partner of LIS1 that participates in the regulation of cytoplasmic dynein function and microtubule… Expand
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Highly Cited
2006
Highly Cited
2006
Expression of transforming acidic coiled-coil containing protein 3 is a novel independent prognostic marker in non-small cell lung cancer.
Transforming acidic coiled-coil containing protein 3 (TACC3) is known to be involved in the control of normal cell growth and… Expand
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Highly Cited
2005
Highly Cited
2005
Aurora A phosphorylation of TACC3/maskin is required for centrosome-dependent microtubule assembly in mitosis
Centrosomes act as sites of microtubule growth, but little is known about how the number and stability of microtubules emanating… Expand
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Highly Cited
2003
Highly Cited
2003
TACC1–chTOG–Aurora A protein complex in breast cancer
The three human TACC (transforming acidic coiled-coil) genes encode a family of proteins with poorly defined functions that are… Expand
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Highly Cited
2002
Highly Cited
2002
The centrosomal protein TACC3 is essential for hematopoietic stem cell function and genetically interfaces with p53‐regulated apoptosis
TACC3 is a centrosomal/mitotic spindle‐associated protein that is highly expressed in a cell cycle‐dependent manner in… Expand
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