J. Gustafsson

Publications1,872
h-index158
Citations116,826
Highly Influential Citations3,814
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Molecular basis of agonism and antagonism in the oestrogen receptor
Oestrogens are involved in the growth, development and homeostasis of a number of tissues. The physiological effects of these steroids are mediated by a ligand-inducible nuclear transcription factor,… Expand
Cloning of a novel receptor expressed in rat prostate and ovary.
We have cloned a novel member of the nuclear receptor superfamily. The cDNA of clone 29 was isolated from a rat prostate cDNA library and it encodes a protein of 485 amino acid residues with a… Expand
Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and beta.
The rat estrogen receptor (ER) exists as two subtypes, ER alpha and ER beta, which differ in the C-terminal ligand binding domain and in the N-terminal transactivation domain. In this study we… Expand
Mechanisms of estrogen action.
Our appreciation of the physiological functions of estrogens and the mechanisms through which estrogens bring about these functions has changed during the past decade. Just as transgenic mice were… Expand
Estrogen receptors: how do they signal and what are their targets.
During the past decade there has been a substantial advance in our understanding of estrogen signaling both from a clinical as well as a preclinical perspective. Estrogen signaling is a balance… Expand
Differential ligand activation of estrogen receptors ERalpha and ERbeta at AP1 sites.
The transactivation properties of the two estrogen receptors, ERalpha and ERbeta, were examined with different ligands in the context of an estrogen response element and an AP1 element. ERalpha and… Expand
Generation and reproductive phenotypes of mice lacking estrogen receptor beta.
Estrogens influence the differentiation and maintenance of reproductive tissues and affect lipid metabolism and bone remodeling. Two estrogen receptors (ERs) have been identified to date, ERalpha and… Expand
Structure of the ligand‐binding domain of oestrogen receptor beta in the presence of a partial agonist and a full antagonist
Oestrogens exert their physiological effects through two receptor subtypes. Here we report the three‐dimensional structure of the oestrogen receptor beta isoform (ERβ) ligand‐binding domain (LBD) in… Expand
Principles for modulation of the nuclear receptor superfamily
Nuclear receptors are major targets for drug discovery and have key roles in development and homeostasis, as well as in many diseases such as obesity, diabetes and cancer. This review provides a… Expand
Estrogen signaling: a subtle balance between ER alpha and ER beta.
The biological actions of estrogens are mediated by estrogen binding to one of two specific estrogen receptors (ERs) ERalpha and ERbeta, which belong to the nuclear receptor superfamily, a family of… Expand
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