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Cloning of a novel receptor expressed in rat prostate and ovary.
- G. Kuiper, E. Enmark, M. Pelto-huikko, S. Nilsson, J. Gustafsson
- BiologyProceedings of the National Academy of Sciences…
- 11 June 1996
It is concluded that clone 29 cDNA encodes a novel rat ER, which is suggested be named rat ERbeta to distinguish it from the previously cloned ER (ERalpha) from rat uterus.
Aire deficient mice develop multiple features of APECED phenotype and show altered immune response.
It is suggested that the Aire gene is not necessary for normal T cell education and development, while a defect in immune response detected in challenged Aire-/- mice underlines the crucial role of AIRE/Aire in maintaining homeostatic regulation in the immune system.
A forkhead gene, FoxE3, is essential for lens epithelial proliferation and closure of the lens vesicle.
- Å. Blixt, M. Mahlapuu, M. Aitola, M. Pelto-huikko, S. Enerbäck, P. Carlsson
- BiologyGenes & development
- 15 January 2000
The cloning of a gene, FoxE3, encoding a forkhead/winged helix transcription factor, which is expressed in the developing lens from the start of lens placode induction and becomes restricted to the anterior proliferating cells when lens fiber differentiation begins is reported.
Human estrogen receptor β-gene structure, chromosomal localization, and expression pattern
Data regarding the genomic structure and chromosomal localization of the human ERβ gene is presented, demonstrating that two independent ER genes do exist in the human and that this receptor is expressed in multiple tissues.
Shedding light on ADAM metalloproteinases.
Human estrogen receptor beta-gene structure, chromosomal localization, and expression pattern.
- E. Enmark, M. Pelto-huikko, J. Gustafsson
- BiologyThe Journal of clinical endocrinology and…
- 1 December 1997
Data is presented regarding the genomic structure and chromosomal localization of the human ER beta gene, demonstrating that two independent ER genes do exist in the human and the tissue distribution of this receptor, showing that this receptor is expressed in multiple tissues.
Estrogen Receptor β Is Coexpressed with ERα and PR and Associated with Nodal Status, Grade, and Proliferation Rate in Breast Cancer
Estrogen receptor beta is coexpressed with ERalpha and PR and associated with nodal status, grade, and proliferation rate in breast cancer.
- T. Järvinen, M. Pelto-huikko, K. Holli, J. Isola
- Medicine, BiologyThe American journal of pathology
The coexpression of ERbeta with ERalpha and PR as well as its association with the other indicators of low biological aggressiveness of breast cancer suggest that ERbeta-positive tumors are likely to respond to hormonal therapy.
Cloning and Characterization of RAP250, a Novel Nuclear Receptor Coactivator*
- F. Caira, P. Antonson, M. Pelto-huikko, E. Treuter, Jan-Åke Gustafsson
- BiologyThe Journal of Biological Chemistry
- 25 February 2000
The cloning and characterization of RAP250 is described, a novel human nuclear receptor coactivator that has a large intrinsic glutamine-rich activation domain and can significantly enhance the transcriptional activity of several nuclear receptors, acting as a coactivators.
Forkhead transcription factor FoxF2 is expressed in mesodermal tissues involved in epithelio‐mesenchymal interactions
- M. Aitola, P. Carlsson, M. Mahlapuu, S. Enerbäck, M. Pelto-huikko
- BiologyDevelopmental dynamics : an official publication…
- 1 May 2000
In this study, in situ hybridization is used to explore the expression pattern of the forkhead transcription factor gene FoxF2 (FREAC‐2, LUN) during mouse and rat embryogenesis, postnatal development, and in adult tissues to demonstrate that foxF2 is expressed in the mesenchyme adjacent to the epithelium in alimentary, respiratory, and urinary tracts, similar to FoxF1.