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Transcription Factor SOX-4, human

Known as: SOX-4, SOX4, Transcription Factor SOX-4 
Transcription factor SOX-4 (474 aa, ~47 kDa) is encoded by the human SOX4 gene. This protein plays a role in both T-cell differentiation and… 
National Institutes of Health

Related topics

Related topics

11 relations
Cell NucleusDNA-Binding ProteinsGenes, RegulatorMorphogenesis

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2016
Highly Cited
2016
lncRNA-UCA1 enhances cell proliferation through functioning as a ceRNA of Sox4 in esophageal cancer.
Esophageal cancer (EC) is one of the most common gastrointestinal cancers, which leads to the sixth ranking of cancer-related… 
Highly Cited
2015
Highly Cited
2015
SOX4 overexpression is a novel biomarker of malignant status and poor prognosis in breast cancer patients
Sex-determining region Y-related high mobility group box 4 (SOX4) has been proven to serve as a critical role in cancer… 
Highly Cited
2013
Highly Cited
2013
SOX4 Mediates TGF-β-Induced Expression of Mesenchymal Markers during Mammary Cell Epithelial to Mesenchymal Transition
The epithelial to mensenchymal transition program regulates various aspects of embryonic development and tissue homeostasis, but… 
Highly Cited
2013
Highly Cited
2013
SOX4 is a direct target gene of FRA-2 and induces expression of HDAC8 in adult T-cell leukemia/lymphoma.
Previously, we have shown that an AP-1 family member, FRA-2, is constitutively expressed in adult T-cell leukemia/lymphoma (ATL… 
Highly Cited
2012
Highly Cited
2012
The transcription factor Sox4 is a downstream target of signaling by the cytokine TGF-β and suppresses TH2 differentiation
Sox4 is a transcription factor that regulates various developmental processes. Here we show that Sox4 was induced by TGF-β and… 
Highly Cited
2012
Highly Cited
2012
The crystal structure of the Sox4 HMG domain-DNA complex suggests a mechanism for positional interdependence in DNA recognition.
It has recently been proposed that the sequence preferences of DNA-binding TFs (transcription factors) can be well described by… 
Highly Cited
2009
Highly Cited
2009
Long-range gene regulation links genomic type 2 diabetes and obesity risk regions to HHEX, SOX4, and IRX3
Genome-wide association studies identified noncoding SNPs associated with type 2 diabetes and obesity in linkage disequilibrium… 
Highly Cited
2008
Highly Cited
2008
The three SoxC proteins—Sox4, Sox11 and Sox12—exhibit overlapping expression patterns and molecular properties
The group C of Sry-related high-mobility group (HMG) box (Sox) transcription factors has three members in most vertebrates: Sox4… 
Highly Cited
2006
Highly Cited
2006
SOX4 expression in bladder carcinoma: clinical aspects and in vitro functional characterization.
The human transcription factor SOX4 was 5-fold up-regulated in bladder tumors compared with normal tissue based on whole-genome… 
Highly Cited
2004
Highly Cited
2004
Purification of neuronal precursors from the adult mouse brain: comprehensive gene expression analysis provides new insights into the control of cell migration, differentiation, and homeostasis
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