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Bace1 modulates myelination in the central and peripheral nervous system
Bace1 is an endopeptidase that cleaves the amyloid precursor protein at the β-secretase site. Apart from this cleavage, the functional importance of Bace1 in other physiological events is unknown. WeExpand
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Mitochondrial dysfunction as a cause of axonal degeneration in multiple sclerosis patients
Degeneration of chronically demyelinated axons is a major cause of irreversible neurological disability in multiple sclerosis (MS) patients. Development of neuroprotective therapies will requireExpand
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Proteolipid Promoter Activity Distinguishes Two Populations of NG2-Positive Cells throughout Neonatal Cortical Development
Transgenic mice expressing enhanced green fluorescent protein (EGFP) driven by the mouse myelin proteolipid protein (PLP) gene promoter have been developed to investigate cells in the oligodendrocyteExpand
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The three SoxC proteins—Sox4, Sox11 and Sox12—exhibit overlapping expression patterns and molecular properties
The group C of Sry-related high-mobility group (HMG) box (Sox) transcription factors has three members in most vertebrates: Sox4, Sox11 and Sox12. Sox4 and Sox11 have key roles in cardiac, neuronalExpand
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Inducible site-specific recombination in myelinating cells.
To explore the function of genes expressed by myelinating cells we have developed a model system that allows for the inducible ablation of predetermined genes in oligodendrocytes and Schwann cells.Expand
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Neurofascins Are Required to Establish Axonal Domains for Saltatory Conduction
Voltage-gated sodium channels are concentrated in myelinated nerves at the nodes of Ranvier flanked by paranodal axoglial junctions. Establishment of these essential nodal and paranodal domains isExpand
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Hyperphosphorylation and insolubility of alpha-synuclein in transgenic mouse oligodendrocytes.
(Oligodendro)glial cytoplasmic inclusions composed of alpha-synuclein (alpha SYN) characterize multiple system atrophy (MSA). Mature oligodendrocytes (OLs) do not normally express alpha SYN, so MSAExpand
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Constitutively Active Akt Induces Enhanced Myelination in the CNS
The serine/threonine kinase Akt regulates multiple cellular functions. The current studies identify a new role for Akt in CNS myelination. In earlier studies on cultured oligodendrocytes, we showedExpand
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Akt Signals through the Mammalian Target of Rapamycin Pathway to Regulate CNS Myelination
Mammalian target of rapamycin (mTOR), a well known Akt substrate, regulates multiple cellular functions including cell growth and protein synthesis. The current study identifies a novel role of theExpand
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Climbing Fiber Innervation of NG2-Expressing Glia in the Mammalian Cerebellum
The molecular layer of the cerebellar cortex is populated by glial progenitors that express ionotropic glutamate receptors and extend numerous processes among Purkinje cell dendrites. Here, we showExpand
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