Long-range gene regulation links genomic type 2 diabetes and obesity risk regions to HHEX, SOX4, and IRX3

@article{Ragvin2009LongrangeGR,
  title={Long-range gene regulation links genomic type 2 diabetes and obesity risk regions to HHEX, SOX4, and IRX3},
  author={Anja Ragvin and E. Moro and D. Fredman and P. Navr{\'a}tilov{\'a} and {\O}yvind Drivenes and P. Engstr{\"o}m and M. Alonso and Elisa de la Calle Mustienes and J. G. Skarmeta and Mar{\'i}a Tavares and F. Casares and M. Manzanares and V. van Heyningen and A. Molven and P. Nj{\o}lstad and F. Argenton and B. Lenhard and T. Becker},
  journal={Proceedings of the National Academy of Sciences},
  year={2009},
  volume={107},
  pages={775 - 780}
}
Genome-wide association studies identified noncoding SNPs associated with type 2 diabetes and obesity in linkage disequilibrium (LD) blocks encompassing HHEX-IDE and introns of CDKAL1 and FTO [Sladek R, et al. (2007) Nature 445:881–885; Steinthorsdottir V, et al. (2007) Nat. Genet 39:770–775; Frayling TM, et al. (2007) Science 316:889–894]. We show that these LD blocks contain highly conserved noncoding elements and overlap with the genomic regulatory blocks of the transcription factor genes… Expand
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