Topical Piperidine Nitroxide MTS-01

Known as: TEMPOL, MTS-01, 1-Piperidinyloxy, 4-Hydroxy-2,2,6,6-tetramethyl- 
A topical gel containing a cell permeable hydrophilic piperidine nitroxide with potential radioprotective and antioxidant activity. As a stable, free… (More)
National Institutes of Health

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tempol

Papers overview

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Highly Cited
2010
Highly Cited
2010
Therapeutic targeting of mitochondrial superoxide in hypertension.
RATIONALE Superoxide (O2(-) ) has been implicated in the pathogenesis of many human diseases including hypertension; however… (More)
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Highly Cited
2010
Highly Cited
2010
Oxidative stress with an activation of the renin-angiotensin system in human vascular endothelial cells as a novel mechanism of uric acid-induced endothelial dysfunction.
AIMS Oxidative stress is known to be a major mechanism of endothelial dysfunction, which plays a key role in the development of… (More)
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Highly Cited
2007
Highly Cited
2007
Podocyte as the target for aldosterone: roles of oxidative stress and Sgk1.
Accumulating evidence suggests that mineralocorticoid receptor blockade effectively reduces proteinuria in hypertensive patients… (More)
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Highly Cited
2005
Highly Cited
2005
Nox1 overexpression potentiates angiotensin II-induced hypertension and vascular smooth muscle hypertrophy in transgenic mice.
BACKGROUND Reactive oxygen species (ROS) have been implicated in the development of cardiovascular pathologies. NAD(P)H oxidases… (More)
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Highly Cited
2004
Highly Cited
2004
Possible contributions of reactive oxygen species and mitogen-activated protein kinase to renal injury in aldosterone/salt-induced hypertensive rats.
Studies were performed to test the hypothesis that reactive oxygen species (ROS) and mitogen-activated protein kinase (MAPK… (More)
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Highly Cited
2003
Highly Cited
2003
Increased reactive oxygen species in rostral ventrolateral medulla contribute to neural mechanisms of hypertension in stroke-prone spontaneously hypertensive rats.
BACKGROUND Oxidative stress increases in hypertension. The aim of this study was to determine whether reactive oxygen species… (More)
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Highly Cited
2001
Highly Cited
2001
Induction of oxyradicals by arsenic: implication for mechanism of genotoxicity.
Although arsenic is a well-established human carcinogen, the mechanisms by which it induces cancer remain poorly understood. We… (More)
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Highly Cited
1999
Highly Cited
1999
Two-week administration of tempol attenuates both hypertension and renal excretion of 8-Iso prostaglandin f2alpha.
8-Iso prostaglandin F2alpha (8-ISO) is formed nonenzymatically from the attack of superoxide radical on arachidonic acid… (More)
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Highly Cited
1998
Highly Cited
1998
Normalization of blood pressure and renal vascular resistance in SHR with a membrane-permeable superoxide dismutase mimetic: role of nitric oxide.
Superoxide radical (O2-) is increased in the vessel wall of spontaneously hypertensive rats (SHR) where its blockade potentiates… (More)
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Review
1994
Review
1994
The redox couple between glutathione and ascorbic acid: a chemical and physiological perspective.
This article provides a comprehensive analysis of the redox reaction between glutathione/glutathione disulfide and ascorbic acid… (More)
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