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Topical Piperidine Nitroxide MTS-01
Known as:
TEMPOL
, MTS-01
, 1-Piperidinyloxy, 4-Hydroxy-2,2,6,6-tetramethyl-
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A topical gel containing a cell permeable hydrophilic piperidine nitroxide with potential radioprotective and antioxidant activity. As a stable, free…
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National Institutes of Health
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tempol
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2017
Highly Cited
2017
High-density polystyrene-grafted silver nanoparticles and their use in the preparation of nanocomposites with antibacterial properties.
Piotr Krystosiak
,
W. Tomaszewski
,
E. Megiel
Journal of Colloid and Interface Science
2017
Corpus ID: 44378345
Highly Cited
2011
Highly Cited
2011
Pulmonary particulate matter and systemic microvascular dysfunction.
T. Nurkiewicz
,
D. Porter
,
+12 authors
V. Castranova
Research report
2011
Corpus ID: 27914781
Pulmonary particulate matter (PM) exposure has been epidemiologically associated with an increased risk of cardiovascular…
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Highly Cited
2004
Highly Cited
2004
Arterial Pressure Response to the Antioxidant Tempol and ETB Receptor Blockade in Rats on a High-Salt Diet
J. Williams
,
J. Pollock
,
D. Pollock
HYPERTENSION
2004
Corpus ID: 6319537
We hypothesized that increased superoxide contributes to mean arterial pressure (MAP) regulation in male Sprague-Dawley rats fed…
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Highly Cited
2004
Highly Cited
2004
Nitric Oxide May Prevent Hypertension Early in Diabetes by Counteracting Renal Actions of Superoxide
M. Brands
,
T. Bell
,
Bradford Gibson
HYPERTENSION
2004
Corpus ID: 15489761
Abstract—The dependence of blood pressure on a balance between superoxide and nitric oxide may be amplified in diabetes. We have…
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2004
2004
Central Tempol alters basal sympathetic nerve discharge and attenuates sympathetic excitation to central ANG II.
Ning Lu
,
B. Helwig
,
R. Fels
,
S. Parimi
,
M. Kenney
American Journal of Physiology. Heart and…
2004
Corpus ID: 13468026
In the present study, we established dose-response relationships between central administration of 4-hydroxy-2,2,6,6…
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Highly Cited
2002
Highly Cited
2002
Induction of apoptosis by chemotherapeutic drugs without generation of reactive oxygen species.
S. Sentürker
,
R. Tschirret-Guth
,
J. Morrow
,
R. Levine
,
E. Shacter
Archives of Biochemistry and Biophysics
2002
Corpus ID: 41794644
Studies in a variety of cell types have suggested that cancer chemotherapy drugs induce tumor cell apoptosis in part by inducing…
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Highly Cited
2001
Highly Cited
2001
Abrin Triggers Cell Death by Inactivating a Thiol-specific Antioxidant Protein*
S. Shih
,
Yu-Hauh Wu
,
C. Hung
,
Hui Y. Yang
,
Jung-Yaw Lin
Journal of Biological Chemistry
2001
Corpus ID: 832917
Abrin A-chain (ABRA) inhibits protein synthesis by its N-glycosidase activity as well as induces apoptosis, but the molecular…
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Highly Cited
1998
Highly Cited
1998
In vivo topical EPR spectroscopy and imaging of nitroxide free radicals and polynitroxyl‐albumin
P. Kuppusamy
,
Penghai Wang
,
+4 authors
J. Zweier
Magnetic Resonance in Medicine
1998
Corpus ID: 10202320
Piperidine nitroxides have considerable clinical potential, both as antioxidant therapeutic compounds and contrast agents in…
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Highly Cited
1992
Highly Cited
1992
Identification of nitroxide radioprotectors.
S. Hahn
,
Lynn Wilson
,
+6 authors
J. Mitchell
Radiation Research
1992
Corpus ID: 31843867
The nitroxide Tempol, a stable free radical, has recently been shown to protect mammalian cells against several forms of…
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Highly Cited
1992
Highly Cited
1992
Antimutagenicity of a low molecular weight superoxide dismutase mimic against oxidative mutagens
W. Degraff
,
M. Krishna
,
A. Russo
,
James B. Mitchell
Environmental and Molecular Mutagenesis
1992
Corpus ID: 24634146
A set of stable nitroxide free radicals that are used as spin labels have been shown to possess metal‐independent superoxide…
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