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Topical Piperidine Nitroxide MTS-01

Known as: TEMPOL, MTS-01, 1-Piperidinyloxy, 4-Hydroxy-2,2,6,6-tetramethyl- 
A topical gel containing a cell permeable hydrophilic piperidine nitroxide with potential radioprotective and antioxidant activity. As a stable, free… 
National Institutes of Health

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tempol

Papers overview

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Highly Cited
2017
Highly Cited
2017
High-density polystyrene-grafted silver nanoparticles and their use in the preparation of nanocomposites with antibacterial properties.
Highly Cited
2011
Highly Cited
2011
Pulmonary particulate matter and systemic microvascular dysfunction.
Pulmonary particulate matter (PM) exposure has been epidemiologically associated with an increased risk of cardiovascular… 
Highly Cited
2004
Highly Cited
2004
Arterial Pressure Response to the Antioxidant Tempol and ETB Receptor Blockade in Rats on a High-Salt Diet
We hypothesized that increased superoxide contributes to mean arterial pressure (MAP) regulation in male Sprague-Dawley rats fed… 
Highly Cited
2004
Highly Cited
2004
Nitric Oxide May Prevent Hypertension Early in Diabetes by Counteracting Renal Actions of Superoxide
Abstract—The dependence of blood pressure on a balance between superoxide and nitric oxide may be amplified in diabetes. We have… 
2004
2004
Central Tempol alters basal sympathetic nerve discharge and attenuates sympathetic excitation to central ANG II.
In the present study, we established dose-response relationships between central administration of 4-hydroxy-2,2,6,6… 
Highly Cited
2002
Highly Cited
2002
Induction of apoptosis by chemotherapeutic drugs without generation of reactive oxygen species.
Studies in a variety of cell types have suggested that cancer chemotherapy drugs induce tumor cell apoptosis in part by inducing… 
Highly Cited
2001
Highly Cited
2001
Abrin Triggers Cell Death by Inactivating a Thiol-specific Antioxidant Protein*
Abrin A-chain (ABRA) inhibits protein synthesis by its N-glycosidase activity as well as induces apoptosis, but the molecular… 
Highly Cited
1998
Highly Cited
1998
In vivo topical EPR spectroscopy and imaging of nitroxide free radicals and polynitroxyl‐albumin
Piperidine nitroxides have considerable clinical potential, both as antioxidant therapeutic compounds and contrast agents in… 
Highly Cited
1992
Highly Cited
1992
Identification of nitroxide radioprotectors.
The nitroxide Tempol, a stable free radical, has recently been shown to protect mammalian cells against several forms of… 
Highly Cited
1992
Highly Cited
1992
Antimutagenicity of a low molecular weight superoxide dismutase mimic against oxidative mutagens
A set of stable nitroxide free radicals that are used as spin labels have been shown to possess metal‐independent superoxide… 
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