Tobramycin

Known as: Nebramycin Factor 6, Nebramycin-Faktor 6, Nebramycin factir 6 
An aminoglycoside antibiotic derived from Streptomyces tenebrarius with bacteriostatic activity. Following active transport into the cell, tobramycin… (More)
National Institutes of Health

Papers overview

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Highly Cited
2011
Highly Cited
2011
BACKGROUND A light-porous-particle, dry-powder formulation of tobramycin was developed, using PulmoSphere® technology, to improve… (More)
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Highly Cited
2005
Highly Cited
2005
The opportunistic human pathogen Pseudomonas aeruginosa is the predominant micro-organism of chronic lung infections in cystic… (More)
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Highly Cited
2005
Highly Cited
2005
Biofilms are adherent aggregates of bacterial cells that form on biotic and abiotic surfaces, including human tissues. Biofilms… (More)
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Highly Cited
2003
Highly Cited
2003
The roles of slow antibiotic penetration, oxygen limitation, and low metabolic activity in the tolerance of Pseudomonas… (More)
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Review
2002
Review
2002
STUDY OBJECTIVES To describe the pharmacokinetics and bioavailability of inhaled tobramycin (TOBI; Chiron Corporation; Seattle… (More)
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Highly Cited
2002
Highly Cited
2002
Detailed knowledge of the composition and structure of the spliceosome and its assembly intermediates is a prerequisite for… (More)
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Highly Cited
2001
Highly Cited
2001
Biofilms are considered to be highly resistant to antimicrobial agents. Strictly speaking, this is not the case-biofilms do not… (More)
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Highly Cited
2000
Highly Cited
2000
We conducted a placebo-controlled, double-blind, randomized study to evaluate the microbiological efficacy and safety of inhaled… (More)
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Highly Cited
1999
Highly Cited
1999
BACKGROUND AND METHODS We conducted two multicenter, double-blind, placebo-controlled trials of intermittent administration of… (More)
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Highly Cited
1993
Highly Cited
1993
BACKGROUND Direct aerosol delivery of aminoglycosides such as tobramycin to the lower airways of patients with cystic fibrosis… (More)
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